Investigating the potential of low concentrations of iron-oxide contrast agents at low magnetic field strengths for the purpose of MR guided interventions

Jordy K. van Zandwijk; Frank F.J. Simonis; Elfi I.S. Hofmeijer; Robert H. Geelkerken; Bernard  ten Haken

Investigating the potential of low concentrations of iron-oxide contrast agents at low magnetic field strengths for the purpose of MR guided interventions

Jordy K. van Zandwijk, Frank F.J. Simonis, Elfi I.S. Hofmeijer, Robert H. Geelkerken, Bernard ten Haken

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Abstract

Iron-oxide contrast agents might prove valuable in endovascular interventions at low-field MRI because their relaxivities are more favorable at lower field strengths, but still maintaining and generating positive contrast. Differences between a range concentrations of a gadolinium-based and a super paramagnetic iron-oxide (SPIO) contrast agent were compared both in simulations and experimentally on 0.25T using three different MR sequences. Optimal contrast for all sequences was found around 0.15mM for the SPIO agent and for concentrations higher than 7.0mM for the gadolinium agent. The use of low concentration SPIOs therefore is more beneficial for imaging at low magnetic field strengths than gadolinium-based contrast agents.

Original language	English
Publication status	Published - 2018
Event	10th Annual ISMRM Benelux Chapter Meeting 2018 - Antwerp Zoo, Belgium, Antwerpen, Belgium Duration: 26 Jan 2018 → 26 Jan 2018 Conference number: 10 http://www.ismrm-benelux.org/

Conference

Conference	10th Annual ISMRM Benelux Chapter Meeting 2018
Country/Territory	Belgium
City	Antwerpen
Period	26/01/18 → 26/01/18
Internet address	http://www.ismrm-benelux.org/

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title = "Investigating the potential of low concentrations of iron-oxide contrast agents at low magnetic field strengths for the purpose of MR guided interventions",

abstract = "Iron-oxide contrast agents might prove valuable in endovascular interventions at low-field MRI because their relaxivities are more favorable at lower field strengths, but still maintaining and generating positive contrast. Differences between a range concentrations of a gadolinium-based and a super paramagnetic iron-oxide (SPIO) contrast agent were compared both in simulations and experimentally on 0.25T using three different MR sequences. Optimal contrast for all sequences was found around 0.15mM for the SPIO agent and for concentrations higher than 7.0mM for the gadolinium agent. The use of low concentration SPIOs therefore is more beneficial for imaging at low magnetic field strengths than gadolinium-based contrast agents.",

author = "{van Zandwijk}, {Jordy K.} and Simonis, {Frank F.J.} and Hofmeijer, {Elfi I.S.} and Geelkerken, {Robert H.} and {ten Haken}, Bernard",

year = "2018",

language = "English",

note = "10th Annual ISMRM Benelux Chapter Meeting 2018 ; Conference date: 26-01-2018 Through 26-01-2018",

url = "http://www.ismrm-benelux.org/",

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Investigating the potential of low concentrations of iron-oxide contrast agents at low magnetic field strengths for the purpose of MR guided interventions. / van Zandwijk, Jordy K.; Simonis, Frank F.J.; Hofmeijer, Elfi I.S. et al.
2018. Abstract from 10th Annual ISMRM Benelux Chapter Meeting 2018, Antwerpen, Belgium.

Research output: Contribution to conference › Abstract › Other research output

TY - CONF

T1 - Investigating the potential of low concentrations of iron-oxide contrast agents at low magnetic field strengths for the purpose of MR guided interventions

AU - van Zandwijk, Jordy K.

AU - Simonis, Frank F.J.

AU - Hofmeijer, Elfi I.S.

AU - Geelkerken, Robert H.

AU - ten Haken, Bernard

N1 - Conference code: 10

PY - 2018

Y1 - 2018

N2 - Iron-oxide contrast agents might prove valuable in endovascular interventions at low-field MRI because their relaxivities are more favorable at lower field strengths, but still maintaining and generating positive contrast. Differences between a range concentrations of a gadolinium-based and a super paramagnetic iron-oxide (SPIO) contrast agent were compared both in simulations and experimentally on 0.25T using three different MR sequences. Optimal contrast for all sequences was found around 0.15mM for the SPIO agent and for concentrations higher than 7.0mM for the gadolinium agent. The use of low concentration SPIOs therefore is more beneficial for imaging at low magnetic field strengths than gadolinium-based contrast agents.

AB - Iron-oxide contrast agents might prove valuable in endovascular interventions at low-field MRI because their relaxivities are more favorable at lower field strengths, but still maintaining and generating positive contrast. Differences between a range concentrations of a gadolinium-based and a super paramagnetic iron-oxide (SPIO) contrast agent were compared both in simulations and experimentally on 0.25T using three different MR sequences. Optimal contrast for all sequences was found around 0.15mM for the SPIO agent and for concentrations higher than 7.0mM for the gadolinium agent. The use of low concentration SPIOs therefore is more beneficial for imaging at low magnetic field strengths than gadolinium-based contrast agents.

M3 - Abstract

T2 - 10th Annual ISMRM Benelux Chapter Meeting 2018

Y2 - 26 January 2018 through 26 January 2018

ER -

Investigating the potential of low concentrations of iron-oxide contrast agents at low magnetic field strengths for the purpose of MR guided interventions

Abstract

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