Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields

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Abstract

Cortical rat neurons were trapped by negative dielectrophoresis (DEP) using a planar quadrupole electrode structure. The non-uniform field created by this structure was calculated using a finite element software package. By representing the neuron by a single-shell model the membrane potential induced by the electric field can be estimated. It was investigated whether the physiological state of the trapped neurons can be predicted using this estimation. Experimentally, the physiological state of cortical cells trapped at different amplitudes and frequencies of the input signal was determined using a staining method. The conclusion is that a rough estimate of the minimum frequency and maximum amplitude can be given in order to predict the status of viability of the cells after being dielectrophoretically trapped.
Original languageUndefined
Title of host publicationProceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey
Place of PublicationPiscattaway, USA
PublisherIEEE
Pages-
Number of pages4
ISBN (Print)0-7803-7213-1
Publication statusPublished - 25 Oct 2001
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001 - Istanbul, Turkey
Duration: 25 Oct 200128 Oct 2001
Conference number: 23

Publication series

Name
PublisherIEEE
Volume1

Conference

Conference23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001
Abbreviated titleEMBC
CountryTurkey
CityIstanbul
Period25/10/0128/10/01

Keywords

  • IR-42180
  • METIS-200704

Cite this

Heida, T., Rutten, W., & Marani, E. (2001). Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields. In Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey (pp. -). Piscattaway, USA: IEEE.
Heida, Tjitske ; Rutten, Wim ; Marani, Enrico. / Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields. Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey. Piscattaway, USA : IEEE, 2001. pp. -
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title = "Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields",
abstract = "Cortical rat neurons were trapped by negative dielectrophoresis (DEP) using a planar quadrupole electrode structure. The non-uniform field created by this structure was calculated using a finite element software package. By representing the neuron by a single-shell model the membrane potential induced by the electric field can be estimated. It was investigated whether the physiological state of the trapped neurons can be predicted using this estimation. Experimentally, the physiological state of cortical cells trapped at different amplitudes and frequencies of the input signal was determined using a staining method. The conclusion is that a rough estimate of the minimum frequency and maximum amplitude can be given in order to predict the status of viability of the cells after being dielectrophoretically trapped.",
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Heida, T, Rutten, W & Marani, E 2001, Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields. in Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey. IEEE, Piscattaway, USA, pp. -, 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001, Istanbul, Turkey, 25/10/01.

Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields. / Heida, Tjitske; Rutten, Wim; Marani, Enrico.

Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey. Piscattaway, USA : IEEE, 2001. p. -.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields

AU - Heida, Tjitske

AU - Rutten, Wim

AU - Marani, Enrico

N1 - CD-rom

PY - 2001/10/25

Y1 - 2001/10/25

N2 - Cortical rat neurons were trapped by negative dielectrophoresis (DEP) using a planar quadrupole electrode structure. The non-uniform field created by this structure was calculated using a finite element software package. By representing the neuron by a single-shell model the membrane potential induced by the electric field can be estimated. It was investigated whether the physiological state of the trapped neurons can be predicted using this estimation. Experimentally, the physiological state of cortical cells trapped at different amplitudes and frequencies of the input signal was determined using a staining method. The conclusion is that a rough estimate of the minimum frequency and maximum amplitude can be given in order to predict the status of viability of the cells after being dielectrophoretically trapped.

AB - Cortical rat neurons were trapped by negative dielectrophoresis (DEP) using a planar quadrupole electrode structure. The non-uniform field created by this structure was calculated using a finite element software package. By representing the neuron by a single-shell model the membrane potential induced by the electric field can be estimated. It was investigated whether the physiological state of the trapped neurons can be predicted using this estimation. Experimentally, the physiological state of cortical cells trapped at different amplitudes and frequencies of the input signal was determined using a staining method. The conclusion is that a rough estimate of the minimum frequency and maximum amplitude can be given in order to predict the status of viability of the cells after being dielectrophoretically trapped.

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BT - Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey

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Heida T, Rutten W, Marani E. Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields. In Proceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey. Piscattaway, USA: IEEE. 2001. p. -