Investigation of the prediction of neural cell survival after exposure to non-uniform electric fields

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    Abstract

    Cortical rat neurons were trapped by negative dielectrophoresis (DEP) using a planar quadrupole electrode structure. The non-uniform field created by this structure was calculated using a finite element software package. By representing the neuron by a single-shell model the membrane potential induced by the electric field can be estimated. It was investigated whether the physiological state of the trapped neurons can be predicted using this estimation. Experimentally, the physiological state of cortical cells trapped at different amplitudes and frequencies of the input signal was determined using a staining method. The conclusion is that a rough estimate of the minimum frequency and maximum amplitude can be given in order to predict the status of viability of the cells after being dielectrophoretically trapped.
    Original languageUndefined
    Title of host publicationProceedings 23rd International Conference of the IEEE Engineering in Medicine and Biology Society, Istanbul, Turkey
    Place of PublicationPiscattaway, USA
    PublisherIEEE
    Pages-
    Number of pages4
    ISBN (Print)0-7803-7213-1
    Publication statusPublished - 25 Oct 2001
    Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001 - Istanbul, Turkey
    Duration: 25 Oct 200128 Oct 2001
    Conference number: 23

    Publication series

    Name
    PublisherIEEE
    Volume1

    Conference

    Conference23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2001
    Abbreviated titleEMBC
    CountryTurkey
    CityIstanbul
    Period25/10/0128/10/01

    Keywords

    • IR-42180
    • METIS-200704

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