Is there a molecular signature of the LCST of single PNIPAM chains as measured by AFM force spectroscopy?

E. Kutnyanszky, A. Embrechts, Mark A. Hempenius, Gyula J. Vancso

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The molecular stretching behavior of temperature responsive poly(N-isopropylacrylamide) (PNIPAM) chains was studied by atomic force microscopy based single molecule force spectroscopy. Force–extension curves obtained in water below and above the lower critical solution temperature, in the co-nonsolvent water/methanol mixture, and in dimethyl sulfoxide (H-bond blocking) follow the same trajectory, independently whether the chain was pulled from a collapsed or from a solvated state. This result indicates that for a single PNIPAM chain the formation of intrachain H-bonds in the precipitated state does not cause measurable chain stiffening at the single chain level.
Original languageUndefined
Pages (from-to)126-130
Number of pages5
JournalChemical physics letters
Publication statusPublished - 2012


  • IR-84743
  • METIS-289593

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