ISFET based enzyme sensors

Bart H. van der Schoot, Piet Bergveld

    Research output: Contribution to journalArticleAcademic

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    This paper reviews the results that have been reported on ISFET based enzyme sensors. The most important improvement that results from the application of ISFETs instead of glass membrane electrodes is in the method of fabrication. Problems with regard to the pH dependence of the response and the dynamic range as well as the influence of the sample buffer capacity have not been solved. As a possible solution we introduce a coulometric system that compensates for the analyte buffer capacity. If the pH in the immobilized enzyme layer is thus controlled, the resulting pH-static enzyme sensor has an output that is independent of the sample pH and buffer capacity and has an expanded linear range.
    Original languageEnglish
    Pages (from-to)161-186
    JournalBiosensors (UK)
    Issue number3
    Publication statusPublished - 1987


    • pH-static enzyme sensor
    • Buffer dependence
    • Coulometry
    • Urea
    • IC technology
    • ISFET
    • Enzyme


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