ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF

Jeroen Krijgsveld (Inventor), Sebastian A.J. Zaat (Inventor), Jacob Dankert (Inventor), A.J. Kuijpers (Inventor), G.H.M. Engbers (Inventor), Jan Feijen, (Inventor)

Research output: PatentProfessional

Abstract

The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.

Original languageEnglish
Patent numberWO9915548
IPCC07K 14/ 52 A I
Priority date1/05/98
Publication statusPublished - 1 Apr 1999

Fingerprint

Mycoses
Bacterial Infections
Peptides
Streptococcus sanguis
Aspergillus flavus
Cryptococcus neoformans
Streptococcus pneumoniae
Endocarditis
Bacillus subtilis
Gram-Negative Bacteria
Candida albicans
Staphylococcus
Epidermis
Staphylococcus aureus
Fungi
Escherichia coli

Cite this

Krijgsveld, J., Zaat, S. A. J., Dankert, J., Kuijpers, A. J., Engbers, G. H. M., & Feijen, J. (1999). IPC No. C07K 14/ 52 A I. ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF. (Patent No. WO9915548).
Krijgsveld, Jeroen (Inventor) ; Zaat, Sebastian A.J. (Inventor) ; Dankert, Jacob (Inventor) ; Kuijpers, A.J. (Inventor) ; Engbers, G.H.M. (Inventor) ; Feijen, Jan (Inventor). / ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF. IPC No.: C07K 14/ 52 A I. Patent No.: WO9915548.
@misc{ecc2aeea50144666b7b3c834e426cfa8,
title = "ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF",
abstract = "The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.",
author = "Jeroen Krijgsveld and Zaat, {Sebastian A.J.} and Jacob Dankert and A.J. Kuijpers and G.H.M. Engbers and Jan Feijen,",
year = "1999",
month = "4",
day = "1",
language = "English",
type = "Patent",
note = "WO9915548; C07K 14/ 52 A I",

}

Krijgsveld, J, Zaat, SAJ, Dankert, J, Kuijpers, AJ, Engbers, GHM & Feijen, J 1999, ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF, Patent No. WO9915548, IPC No. C07K 14/ 52 A I.

ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF. / Krijgsveld, Jeroen (Inventor); Zaat, Sebastian A.J. (Inventor); Dankert, Jacob (Inventor); Kuijpers, A.J. (Inventor); Engbers, G.H.M. (Inventor); Feijen, Jan (Inventor).

IPC No.: C07K 14/ 52 A I. Patent No.: WO9915548.

Research output: PatentProfessional

TY - PAT

T1 - ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF

AU - Krijgsveld, Jeroen

AU - Zaat, Sebastian A.J.

AU - Dankert, Jacob

AU - Kuijpers, A.J.

AU - Engbers, G.H.M.

AU - Feijen,, Jan

PY - 1999/4/1

Y1 - 1999/4/1

N2 - The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.

AB - The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.

M3 - Patent

M1 - WO9915548

ER -

Krijgsveld J, Zaat SAJ, Dankert J, Kuijpers AJ, Engbers GHM, Feijen, J, inventors. ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF. C07K 14/ 52 A I. 1999 Apr 1.