TY - PAT
T1 - ISOLATED AND RECOMBINANT ANTIMICROBIAL PEPTIDES THROMBOCIDIN-1 (TC-1) AND THROMBOCIDIN-2 (TC-2) OR VARIANTS THEREOF
AU - Krijgsveld, Jeroen
AU - Zaat, Sebastian A.J.
AU - Dankert, Jacob
AU - Kuijpers, A.J.
AU - Engbers, G.H.M.
AU - Feijen,, Jan
PY - 1999/4/1
Y1 - 1999/4/1
N2 - The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.
AB - The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in figure 1 indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example Escherichia coli, Bacillus subtilis, Streptococcus sanguis, Streptococcus pneumoniae, Staphylococcus epidermis, and Staphylococcus aureus, and/or against fungi, for example Candida albicans, C. glabarata, Cryptococcus neoformans, Aspergillus flavus, A. fumigatus, and Pseudoallescheria spec.. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in human and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in human and animals.
M3 - Patent
M1 - WO9915548
ER -