Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms

M. Brivio; A. Liesner; R.E. Oosterbroek; Willem Verboom; U. Karst; Albert van den Berg; David Reinhoudt

Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms

M. Brivio, A. Liesner, R.E. Oosterbroek, Willem Verboom, U. Karst, Albert van den Berg, David Reinhoudt

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

A high-throughput method is presented for the study of reaction kinetics by nano- electrospray ionization mass spectrometry (nano-ESI MS). The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7- piperazino-2,1,3-benzoxadiazole (NBDPZ) (1) to yield the corresponding urea derivatives (5) was carried out in a continuous flow glass microchip. Real-time monitoring of the reactions was done by nano-ESI MS. Rate constants of 1.6 ⿣ 104 M-1 min-1, 5.2 ⿣ 104 M-1 min-1, and 2.5 ⿣ 104 M-1 min-1 were determined for isocyanate 2, 3 and 4, respectively.

Original language	English
Title of host publication	MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Editors	K.F Jensen, J. Han, D.J. Harrison, J. Voldman
Place of Publication	San Diego, CA, USA
Publisher	Transducer Research Foundation, Inc.
Pages	927-929
Number of pages	3
ISBN (Print)	0-9743611-1-9
Publication status	Published - 9 Oct 2005
Event	9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005 - Boston, United States Duration: 9 Oct 2005 → 13 Oct 2005 Conference number: 9

Publication series

Name
Publisher	Transducer Research Foundation, Inc.
Volume	2

Conference

Conference	9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005
Abbreviated title	MicroTAS
Country/Territory	United States
City	Boston
Period	9/10/05 → 13/10/05

Keywords

METIS-224693
IR-52865
Reaction kinetics
EWI-19992
nano-ESI MS
real-time monitoring
Micro-reactor

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Brivio, M., Liesner, A., Oosterbroek, R. E., Verboom, W., Karst, U., van den Berg, A., & Reinhoudt, D. (2005). Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. In K. F. Jensen, J. Han, D. J. Harrison, & J. Voldman (Eds.), MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 927-929). Transducer Research Foundation, Inc..

Brivio, M. ; Liesner, A. ; Oosterbroek, R.E. et al. / Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. editor / K.F Jensen ; J. Han ; D.J. Harrison ; J. Voldman. San Diego, CA, USA : Transducer Research Foundation, Inc., 2005. pp. 927-929

@inproceedings{c9b20839dc2a42b7ae4dd7b0953fa448,

title = "Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms",

abstract = "A high-throughput method is presented for the study of reaction kinetics by nano- electrospray ionization mass spectrometry (nano-ESI MS). The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7- piperazino-2,1,3-benzoxadiazole (NBDPZ) (1) to yield the corresponding urea derivatives (5) was carried out in a continuous flow glass microchip. Real-time monitoring of the reactions was done by nano-ESI MS. Rate constants of 1.6 ⿣ 104 M-1 min-1, 5.2 ⿣ 104 M-1 min-1, and 2.5 ⿣ 104 M-1 min-1 were determined for isocyanate 2, 3 and 4, respectively.",

keywords = "METIS-224693, IR-52865, Reaction kinetics, EWI-19992, nano-ESI MS, real-time monitoring, Micro-reactor",

author = "M. Brivio and A. Liesner and R.E. Oosterbroek and Willem Verboom and U. Karst and {van den Berg}, Albert and David Reinhoudt",

year = "2005",

month = oct,

day = "9",

language = "English",

isbn = "0-9743611-1-9",

publisher = "Transducer Research Foundation, Inc.",

pages = "927--929",

editor = "K.F Jensen and J. Han and D.J. Harrison and J. Voldman",

booktitle = "MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

note = "9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005, MicroTAS ; Conference date: 09-10-2005 Through 13-10-2005",

}

Brivio, M, Liesner, A, Oosterbroek, RE, Verboom, W, Karst, U, van den Berg, A & Reinhoudt, D 2005, Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. in KF Jensen, J Han, DJ Harrison & J Voldman (eds), MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Transducer Research Foundation, Inc., San Diego, CA, USA, pp. 927-929, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005, Boston, Massachusetts, United States, 9/10/05.

Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. / Brivio, M.; Liesner, A.; Oosterbroek, R.E. et al.
MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. ed. / K.F Jensen; J. Han; D.J. Harrison; J. Voldman. San Diego, CA, USA: Transducer Research Foundation, Inc., 2005. p. 927-929.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms

AU - Brivio, M.

AU - Liesner, A.

AU - Oosterbroek, R.E.

AU - Verboom, Willem

AU - Karst, U.

AU - van den Berg, Albert

AU - Reinhoudt, David

N1 - Conference code: 9

PY - 2005/10/9

Y1 - 2005/10/9

N2 - A high-throughput method is presented for the study of reaction kinetics by nano- electrospray ionization mass spectrometry (nano-ESI MS). The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7- piperazino-2,1,3-benzoxadiazole (NBDPZ) (1) to yield the corresponding urea derivatives (5) was carried out in a continuous flow glass microchip. Real-time monitoring of the reactions was done by nano-ESI MS. Rate constants of 1.6 ⿣ 104 M-1 min-1, 5.2 ⿣ 104 M-1 min-1, and 2.5 ⿣ 104 M-1 min-1 were determined for isocyanate 2, 3 and 4, respectively.

AB - A high-throughput method is presented for the study of reaction kinetics by nano- electrospray ionization mass spectrometry (nano-ESI MS). The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7- piperazino-2,1,3-benzoxadiazole (NBDPZ) (1) to yield the corresponding urea derivatives (5) was carried out in a continuous flow glass microchip. Real-time monitoring of the reactions was done by nano-ESI MS. Rate constants of 1.6 ⿣ 104 M-1 min-1, 5.2 ⿣ 104 M-1 min-1, and 2.5 ⿣ 104 M-1 min-1 were determined for isocyanate 2, 3 and 4, respectively.

KW - METIS-224693

KW - IR-52865

KW - Reaction kinetics

KW - EWI-19992

KW - nano-ESI MS

KW - real-time monitoring

KW - Micro-reactor

M3 - Conference contribution

SN - 0-9743611-1-9

SP - 927

EP - 929

BT - MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences

A2 - Jensen, K.F

A2 - Han, J.

A2 - Harrison, D.J.

A2 - Voldman, J.

PB - Transducer Research Foundation, Inc.

CY - San Diego, CA, USA

T2 - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005

Y2 - 9 October 2005 through 13 October 2005

ER -

Brivio M, Liesner A, Oosterbroek RE, Verboom W, Karst U, van den Berg A et al. Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. In Jensen KF, Han J, Harrison DJ, Voldman J, editors, MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences. San Diego, CA, USA: Transducer Research Foundation, Inc. 2005. p. 927-929

Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms

Abstract

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Keywords

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