Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms

M. Brivio, A. Liesner, R.E. Oosterbroek, Willem Verboom, U. Karst, Albert van den Berg, David Reinhoudt

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Abstract

A high-throughput method is presented for the study of reaction kinetics by nano- electrospray ionization mass spectrometry (nano-ESI MS). The reaction of propyl isocyanate (2), benzyl isocyanate (3), and toluene-2,4-diisocyanate (4) with 4-nitro-7- piperazino-2,1,3-benzoxadiazole (NBDPZ) (1) to yield the corresponding urea derivatives (5) was carried out in a continuous flow glass microchip. Real-time monitoring of the reactions was done by nano-ESI MS. Rate constants of 1.6 ⿣ 104 M-1 min-1, 5.2 ⿣ 104 M-1 min-1, and 2.5 ⿣ 104 M-1 min-1 were determined for isocyanate 2, 3 and 4, respectively.
Original languageEnglish
Title of host publicationMicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
EditorsK.F Jensen, J. Han, D.J. Harrison, J. Voldman
Place of PublicationSan Diego, CA, USA
PublisherTransducer Research Foundation, Inc.
Pages927-929
Number of pages3
ISBN (Print)0-9743611-1-9
Publication statusPublished - 9 Oct 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005 - Boston, United States
Duration: 9 Oct 200513 Oct 2005
Conference number: 9

Publication series

Name
PublisherTransducer Research Foundation, Inc.
Volume2

Conference

Conference9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2005
Abbreviated titleMicroTAS
CountryUnited States
CityBoston
Period9/10/0513/10/05

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Keywords

  • METIS-224693
  • IR-52865
  • Reaction kinetics
  • EWI-19992
  • nano-ESI MS
  • real-time monitoring
  • Micro-reactor

Cite this

Brivio, M., Liesner, A., Oosterbroek, R. E., Verboom, W., Karst, U., van den Berg, A., & Reinhoudt, D. (2005). Kinetic study of an on-chip isocyanate derivatization reaction by on-line nano-esi ms. In K. F. Jensen, J. Han, D. J. Harrison, & J. Voldman (Eds.), MicroTAS 2005 Conference - 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 927-929). San Diego, CA, USA: Transducer Research Foundation, Inc..