Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration

E.E. Krommenhoek, Michiel van Leeuwen, Johannes G.E. Gardeniers, Walter M. van Gulik, Albert van den Berg, X. Li, Xiaonan Li, Marcel Ottens, Luuk A.M. van der Wielen, Joseph J. Heijnen

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52 Citations (Scopus)


Miniaturization and automation are highly important issues for the development of high-throughput processes. The area of micro total analysis systems (mu TAS) is growing rapidly and the design of new schemes which are suitable for miniaturized analytical devices is of great importance. In this paper we report the immobilization of self-assembled monolayers (SAMs) with metal ion sensing properties, on the walls of glass microchannels. The parallel combinatorial synthesis of sensing SAMs in individually addressable microchannels towards the generation of optical sensor arrays and sensing chips has been developed.
Original languageUndefined
Pages (from-to)884-892
Number of pages9
JournalBiotechnology and bioengineering
Issue number4
Publication statusPublished - 1 Mar 2008


  • METIS-246036
  • IR-60701
  • EWI-12160

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