Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration

E.E. Krommenhoek, Michiel van Leeuwen, Johannes G.E. Gardeniers, Walter M. van Gulik, Albert van den Berg, X. Li, Xiaonan Li, Marcel Ottens, Luuk A.M. van der Wielen, Joseph J. Heijnen

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)

Abstract

Miniaturization and automation are highly important issues for the development of high-throughput processes. The area of micro total analysis systems (mu TAS) is growing rapidly and the design of new schemes which are suitable for miniaturized analytical devices is of great importance. In this paper we report the immobilization of self-assembled monolayers (SAMs) with metal ion sensing properties, on the walls of glass microchannels. The parallel combinatorial synthesis of sensing SAMs in individually addressable microchannels towards the generation of optical sensor arrays and sensing chips has been developed.
Original languageUndefined
Pages (from-to)884-892
Number of pages9
JournalBiotechnology and bioengineering
Volume99
Issue number4
DOIs
Publication statusPublished - 1 Mar 2008

Keywords

  • METIS-246036
  • IR-60701
  • EWI-12160

Cite this

Krommenhoek, E.E. ; van Leeuwen, Michiel ; Gardeniers, Johannes G.E. ; van Gulik, Walter M. ; van den Berg, Albert ; Li, X. ; Li, Xiaonan ; Ottens, Marcel ; van der Wielen, Luuk A.M. ; Heijnen, Joseph J. / Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration. In: Biotechnology and bioengineering. 2008 ; Vol. 99, No. 4. pp. 884-892.
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Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration. / Krommenhoek, E.E.; van Leeuwen, Michiel; Gardeniers, Johannes G.E.; van Gulik, Walter M.; van den Berg, Albert; Li, X.; Li, Xiaonan; Ottens, Marcel; van der Wielen, Luuk A.M.; Heijnen, Joseph J.

In: Biotechnology and bioengineering, Vol. 99, No. 4, 01.03.2008, p. 884-892.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Lab-scale fermentation tests of microchip with integrated electrochemical sensors for pH, temperature, dissolved oxygen and viable biomass concentration

AU - Krommenhoek, E.E.

AU - van Leeuwen, Michiel

AU - Gardeniers, Johannes G.E.

AU - van Gulik, Walter M.

AU - van den Berg, Albert

AU - Li, X.

AU - Li, Xiaonan

AU - Ottens, Marcel

AU - van der Wielen, Luuk A.M.

AU - Heijnen, Joseph J.

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N2 - Miniaturization and automation are highly important issues for the development of high-throughput processes. The area of micro total analysis systems (mu TAS) is growing rapidly and the design of new schemes which are suitable for miniaturized analytical devices is of great importance. In this paper we report the immobilization of self-assembled monolayers (SAMs) with metal ion sensing properties, on the walls of glass microchannels. The parallel combinatorial synthesis of sensing SAMs in individually addressable microchannels towards the generation of optical sensor arrays and sensing chips has been developed.

AB - Miniaturization and automation are highly important issues for the development of high-throughput processes. The area of micro total analysis systems (mu TAS) is growing rapidly and the design of new schemes which are suitable for miniaturized analytical devices is of great importance. In this paper we report the immobilization of self-assembled monolayers (SAMs) with metal ion sensing properties, on the walls of glass microchannels. The parallel combinatorial synthesis of sensing SAMs in individually addressable microchannels towards the generation of optical sensor arrays and sensing chips has been developed.

KW - METIS-246036

KW - IR-60701

KW - EWI-12160

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