Labs and Organs on Chip for Health and Environment

Albert van den Berg*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Abstract

The recent rapid developments in bionanotech and micro/nanofluidic technologies has enabled the realization of miniaturized laboratories. These Labs-on-a-Chip will play an important role in future medicine, both in point-of-care devices for drug or biomarker monitoring, as well as in early diagnostic devices. Microfluidics can also be exploited to manipulate and experiment with cells on chip. We have developed a microsystem for sperm analysis and selection for artificial insemination, where we can electrically detect and sort healthy sperm cells. Apart from diagnostic and cell manipulation devices, microfluidic devices are increasingly used to realise advanced disease and organ-models, as illustrated by the blood-brain barrier chip, a blood vessel on a chip to study atherosclerosis and cancer spheroids on chip for dynamic drug dosing. These Organs on Chip may lead to more rapid and cheaper drug development, personalised medicine and improved disease models, while minimizing or even eliminating animal testing (3R principle). We have developed a Translational Organ on Chip Platform (TOP) that enables simple plug and play connection of different Organ on Chip modules to a fluidic base plate. Finally, a microfluidic impedance spectroscopy system will be presented that can monitor the calcification of coccolithophores (algae), which plays an important role in the oceanic carbon cycle.
Original languageEnglish
Title of host publication2023 IEEE Nanotechnology Materials and Devices Conference (NMDC)
PublisherIEEE
Pages570-570
Number of pages1
ISBN (Electronic)979-8-3503-3546-0
DOIs
Publication statusPublished - 12 Dec 2023
Event18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023 - Paestum, Italy
Duration: 22 Oct 202325 Oct 2023
Conference number: 18

Publication series

NameIEEE Nanotechnology Materials and Devices Conference (NMDC)
PublisherIEEE
ISSN (Print)2378-377X
ISSN (Electronic)2473-0718

Conference

Conference18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023
Abbreviated titleNMDC 2023
Country/TerritoryItaly
CityPaestum
Period22/10/2325/10/23

Keywords

  • 2024 OA procedure
  • Microphysiological Systems
  • Microfluidic Device
  • Marine Carbon
  • Cancer Spheroids
  • Chip Platform

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