LABS, cells and organs on chip: Technologies and biomedical applications

Albert Van Den Berg*

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    1 Citation (Scopus)
    2 Downloads (Pure)

    Abstract

    Over the past few decades both micro/ nanofabrication and microfluidics technologies have been crucial for the rapid development of Lab on a Chip systems. Here we present a few examples of this. Firstly, a capillary electrophoresis system on chip for blood analysis will be presented. Secondly, we show how nanostructures enable new chemical sensors and how they can be exploited to obtain highly sensitive and uniform SERS surfaces, enabling sensitive biomolecule detection and allowing simultaneous electrochemical experimentation. Then we present a microfluidic device in which we can trap and electroporate individual cells to study gene transfection. Finally, we show how Lab on a Chip systems can be used to realize so-called 'Organs on Chip' that mimic functional organ behavior. In particular a Blood Brain Barrier ('BBB chip') is presented to study behavior of tight junctions, while we also demonstrate a microfluidic chip mimicking atherosclerosis, and show how thrombus formation around narrowing in the artificial blood vessel takes place. These examples clearly demonstrate the power and future potential of such microsystems for biomedical applications.

    Original languageEnglish
    Title of host publicationTRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems
    PublisherIEEE
    Pages6-9
    Number of pages4
    ISBN (Electronic)9781538627310
    DOIs
    Publication statusPublished - 26 Jul 2017
    Event19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017 - Kaohsiung, Taiwan, Province of China
    Duration: 18 Jun 201722 Jun 2017
    Conference number: 19
    http://transducers2017.org/

    Conference

    Conference19th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2017
    Abbreviated titleTRANSDUCERS
    CountryTaiwan, Province of China
    CityKaohsiung
    Period18/06/1722/06/17
    Internet address

    Keywords

    • Lab-on-a-chip
    • micro/nanofabrication
    • microfluidics
    • organ on chip

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  • Cite this

    Van Den Berg, A. (2017). LABS, cells and organs on chip: Technologies and biomedical applications. In TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 6-9). [7993974] IEEE. https://doi.org/10.1109/TRANSDUCERS.2017.7993974