Large-scale microstructural simulation of load-adaptive bone remodeling in whole human vertebrae

Sandro D. Badilatti, Patrik Christen, Alina Levchuk, Javad Hazrati Marangalou, Bert van Rietbergen, Ian Parkinson, Ralph Müller

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Identification of individuals at risk of bone fractures remains challenging despite recent advances in bone strength assessment. In particular, the future degradation of the microstructure and load adaptation has been disregarded. Bone remodeling simulations have so far been restricted to small-volume samples. Here, we present a large-scale framework for predicting microstructural adaptation in whole human vertebrae. The load-adaptive bone remodeling simulations include estimations of appropriate bone loading of three load cases as boundary conditions with microfinite element analysis. Homeostatic adaptation of whole human vertebrae over a simulated period of 10 years is achieved with changes in bone volume fraction (BV/TV) of less than 5 %. Evaluation on subvolumes shows that simplifying boundary conditions reduces the ability of the system to maintain trabecular structures when keeping remodeling parameters unchanged. By rotating the loading direction, adaptation toward new loading conditions could be induced. This framework shows the possibility of using large-scale bone remodeling simulations toward a more accurate prediction of microstructural changes in whole human bones.
Original languageEnglish
Pages (from-to)83-95
JournalBiomechanics and modeling in mechanobiology
Volume15
Issue number1
DOIs
Publication statusPublished - 2016

Fingerprint

Bone Remodeling
Bone
Spine
Bone and Bones
Simulation
Bone Fractures
Boundary conditions
Remodeling
Volume Fraction
Microstructure
Rotating
Degradation
Human
Prediction
Evaluation
Volume fraction

Keywords

  • METIS-319017
  • IR-102199

Cite this

Badilatti, Sandro D. ; Christen, Patrik ; Levchuk, Alina ; Hazrati Marangalou, Javad ; van Rietbergen, Bert ; Parkinson, Ian ; Müller, Ralph. / Large-scale microstructural simulation of load-adaptive bone remodeling in whole human vertebrae. In: Biomechanics and modeling in mechanobiology. 2016 ; Vol. 15, No. 1. pp. 83-95.
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Large-scale microstructural simulation of load-adaptive bone remodeling in whole human vertebrae. / Badilatti, Sandro D.; Christen, Patrik; Levchuk, Alina; Hazrati Marangalou, Javad; van Rietbergen, Bert; Parkinson, Ian; Müller, Ralph.

In: Biomechanics and modeling in mechanobiology, Vol. 15, No. 1, 2016, p. 83-95.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Badilatti, Sandro D.

AU - Christen, Patrik

AU - Levchuk, Alina

AU - Hazrati Marangalou, Javad

AU - van Rietbergen, Bert

AU - Parkinson, Ian

AU - Müller, Ralph

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AB - Identification of individuals at risk of bone fractures remains challenging despite recent advances in bone strength assessment. In particular, the future degradation of the microstructure and load adaptation has been disregarded. Bone remodeling simulations have so far been restricted to small-volume samples. Here, we present a large-scale framework for predicting microstructural adaptation in whole human vertebrae. The load-adaptive bone remodeling simulations include estimations of appropriate bone loading of three load cases as boundary conditions with microfinite element analysis. Homeostatic adaptation of whole human vertebrae over a simulated period of 10 years is achieved with changes in bone volume fraction (BV/TV) of less than 5 %. Evaluation on subvolumes shows that simplifying boundary conditions reduces the ability of the system to maintain trabecular structures when keeping remodeling parameters unchanged. By rotating the loading direction, adaptation toward new loading conditions could be induced. This framework shows the possibility of using large-scale bone remodeling simulations toward a more accurate prediction of microstructural changes in whole human bones.

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