Laser-activated microparticles for multimodal imaging: ultrasound and photoacoustics

Mirjam Visscher, Guillaume Lajoinie, Emilie Blazejewski, Gert Veldhuis, Michel Versluis (Corresponding Author)

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Abstract

The increasing personalization of medical treatment demands refined imaging and increased monitoring capabilities, as well as an improved efficacy through targeted drug delivery. Such a transition in health care can be facilitated by the use of multimodal contrast agents. In this paper, we present a novel type of multimodal contrast agents, that enhances contrast both in ultrasound and in photoacoustic imaging, while at the same time being capable of triggered drug delivery. Upon pulsed laser irradiation, polymeric microparticles-containing a dye and an oil core-can create a cavitation bubble that subsequently emits a strong acoustic wave. We investigated different formulations of these particles, by changing the oil content, dye concentration and probing conditions using a combination of pulsed laser excitation and an ultrasound chirp. We demonstrated that capsules with a core containing a low boiling point oil give the highest photoacoustic and acoustic response. The laser activation threshold for this system is high in the visible range, but within the near infrared medical limits. The same system also produces a stable bubble. US scattering by these stable bubbles results in medically relevant frequencies, making the particles of interest for biomedical and pre-clinical imaging. Finally, the system has potential to carry a functional drug-load, and a route to these applications is discussed.

Original languageEnglish
Article number034001
Number of pages14
JournalPhysics in medicine and biology
Volume64
Issue number3
DOIs
Publication statusPublished - 29 Jan 2019

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Multimodal Imaging
Oils
Lasers
Contrast Media
Coloring Agents
Pharmaceutical Preparations
Patient Transfer
Acoustics
Capsules
Therapeutics

Cite this

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title = "Laser-activated microparticles for multimodal imaging: ultrasound and photoacoustics",
abstract = "The increasing personalization of medical treatment demands refined imaging and increased monitoring capabilities, as well as an improved efficacy through targeted drug delivery. Such a transition in health care can be facilitated by the use of multimodal contrast agents. In this paper, we present a novel type of multimodal contrast agents, that enhances contrast both in ultrasound and in photoacoustic imaging, while at the same time being capable of triggered drug delivery. Upon pulsed laser irradiation, polymeric microparticles-containing a dye and an oil core-can create a cavitation bubble that subsequently emits a strong acoustic wave. We investigated different formulations of these particles, by changing the oil content, dye concentration and probing conditions using a combination of pulsed laser excitation and an ultrasound chirp. We demonstrated that capsules with a core containing a low boiling point oil give the highest photoacoustic and acoustic response. The laser activation threshold for this system is high in the visible range, but within the near infrared medical limits. The same system also produces a stable bubble. US scattering by these stable bubbles results in medically relevant frequencies, making the particles of interest for biomedical and pre-clinical imaging. Finally, the system has potential to carry a functional drug-load, and a route to these applications is discussed.",
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Laser-activated microparticles for multimodal imaging : ultrasound and photoacoustics. / Visscher, Mirjam; Lajoinie, Guillaume; Blazejewski, Emilie; Veldhuis, Gert; Versluis, Michel (Corresponding Author).

In: Physics in medicine and biology, Vol. 64, No. 3, 034001, 29.01.2019.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Versluis, Michel

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