TY - JOUR
T1 - Laser Doppler Flowmetry Combined with Spectroscopy to Determine Peripheral Tissue Perfusion and Oxygen Saturation
T2 - A Pilot Study in Healthy Volunteers and Patients with Peripheral Arterial Disease
AU - Ma, Kirsten F.
AU - Kleiss, Simone F.
AU - Schuurmann, Richte C.L.
AU - Nijboer, Thomas S.
AU - El Moumni, Mostafa
AU - Bokkers, Reinoud P.H.
AU - de Vries, Jean Paul P.M.
N1 - Funding Information:
Perimed AB (Järfälla, Stockholm, Sweden) provided the PeriFlux 6000 enhanced perfusion and oxygen saturation (EPOS) system for this research.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6
Y1 - 2022/6
N2 - Background: In this study, we assessed the ability of the EPOS system (Perimed AB, Järfälla, Stockholm, Sweden) to detect differences in tissue perfusion between healthy volunteers and patients with peripheral arterial disease (PAD) with different severity of disease. Methods: This single-center prospective pilot study included 10 healthy volunteers and 20 patients with PAD scheduled for endovascular therapy (EVT). EPOS measurements were performed at rest at 32◦C and 44◦C, followed by transcutaneous oxygen pressure (TcPO2) measurements. The measurements were performed on the dorsal and medial side of the foot, as well as the lateral side of the calf. EPOS parameters included hemoglobin oxygen saturation (HbSO2) and speed-resolved red blood cell (RBC) perfusion. Results: HbSO2 at 44◦C was significantly different between the three groups for all measurement locations. The overall speed-resolved RBC perfusion at 44◦C was statistically significant between the groups on the dorsal and medial side of the foot but not on the calf. TcPO2 values were not significantly different between the three groups. Conclusions: This study demonstrates that the EPOS system can depict differences in tissue perfusion between healthy volunteers, patients with Fontaine class IIb PAD, and those with Fontaine class III or IV PAD but only after heating to 44◦C.
AB - Background: In this study, we assessed the ability of the EPOS system (Perimed AB, Järfälla, Stockholm, Sweden) to detect differences in tissue perfusion between healthy volunteers and patients with peripheral arterial disease (PAD) with different severity of disease. Methods: This single-center prospective pilot study included 10 healthy volunteers and 20 patients with PAD scheduled for endovascular therapy (EVT). EPOS measurements were performed at rest at 32◦C and 44◦C, followed by transcutaneous oxygen pressure (TcPO2) measurements. The measurements were performed on the dorsal and medial side of the foot, as well as the lateral side of the calf. EPOS parameters included hemoglobin oxygen saturation (HbSO2) and speed-resolved red blood cell (RBC) perfusion. Results: HbSO2 at 44◦C was significantly different between the three groups for all measurement locations. The overall speed-resolved RBC perfusion at 44◦C was statistically significant between the groups on the dorsal and medial side of the foot but not on the calf. TcPO2 values were not significantly different between the three groups. Conclusions: This study demonstrates that the EPOS system can depict differences in tissue perfusion between healthy volunteers, patients with Fontaine class IIb PAD, and those with Fontaine class III or IV PAD but only after heating to 44◦C.
KW - diffuse reflectance spectroscopy
KW - endovascular procedures
KW - laser Doppler flowmetry
KW - peripheral arterial disease
KW - tissue perfusion
UR - https://www.scopus.com/pages/publications/85131365622
U2 - 10.3390/jpm12060853
DO - 10.3390/jpm12060853
M3 - Article
AN - SCOPUS:85131365622
SN - 2075-4426
VL - 12
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 6
M1 - 853
ER -
