Laser-driven resonance of dye-doped oil-coated microbubbles: Experimental study

Guillaume Lajoinie, Jeong-Yu Lee, Joshua Owen, Pieter Kruizinga, Nico de Jong, Gijs van Soest, Eleanor Stride, Michel Versluis

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Abstract

Photoacoustic (PA) imaging offers several attractive features as a biomedical imaging modality, including excellent spatial resolution and functional information such as tissue oxygenation. A key limitation, however, is the contrast to noise ratio that can be obtained from tissue depths greater than 1–2 mm. Microbubbles coated with an optically absorbing shell have been proposed as a possible contrast agent for PA imaging, offering greater signal amplification and improved biocompatibility compared to metallic nanoparticles. A theoretical description of the dynamics of a coated microbubble subject to laser irradiation has been developed previously. The aim of this study was to test the predictions of the model. Two different types of oil-coated microbubbles were fabricated and then exposed to both pulsed and continuous wave (CW) laser irradiation. Their response was characterized using ultra high-speed imaging. Although there was considerable variability across the population, good agreement was found between the experimental results and theoretical predictions in terms of the frequency and amplitude of microbubble oscillation following pulsed excitation. Under CW irradiation, highly nonlinear behavior was observed which may be of considerable interest for developing different PA imaging techniques with greatly improved contrast enhancement.
Original languageEnglish
Pages (from-to)4832-4846
JournalJournal of the Acoustical Society of America
Volume141
Issue number6
DOIs
Publication statusPublished - Jun 2017

Cite this

Lajoinie, Guillaume ; Lee, Jeong-Yu ; Owen, Joshua ; Kruizinga, Pieter ; de Jong, Nico ; van Soest, Gijs ; Stride, Eleanor ; Versluis, Michel. / Laser-driven resonance of dye-doped oil-coated microbubbles: Experimental study. In: Journal of the Acoustical Society of America. 2017 ; Vol. 141, No. 6. pp. 4832-4846.
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abstract = "Photoacoustic (PA) imaging offers several attractive features as a biomedical imaging modality, including excellent spatial resolution and functional information such as tissue oxygenation. A key limitation, however, is the contrast to noise ratio that can be obtained from tissue depths greater than 1–2 mm. Microbubbles coated with an optically absorbing shell have been proposed as a possible contrast agent for PA imaging, offering greater signal amplification and improved biocompatibility compared to metallic nanoparticles. A theoretical description of the dynamics of a coated microbubble subject to laser irradiation has been developed previously. The aim of this study was to test the predictions of the model. Two different types of oil-coated microbubbles were fabricated and then exposed to both pulsed and continuous wave (CW) laser irradiation. Their response was characterized using ultra high-speed imaging. Although there was considerable variability across the population, good agreement was found between the experimental results and theoretical predictions in terms of the frequency and amplitude of microbubble oscillation following pulsed excitation. Under CW irradiation, highly nonlinear behavior was observed which may be of considerable interest for developing different PA imaging techniques with greatly improved contrast enhancement.",
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Laser-driven resonance of dye-doped oil-coated microbubbles: Experimental study. / Lajoinie, Guillaume; Lee, Jeong-Yu; Owen, Joshua; Kruizinga, Pieter; de Jong, Nico; van Soest, Gijs; Stride, Eleanor; Versluis, Michel.

In: Journal of the Acoustical Society of America, Vol. 141, No. 6, 06.2017, p. 4832-4846.

Research output: Contribution to journalArticleAcademicpeer-review

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