Latency dependent development of related firing patterns of cultured cortical neurons

Jakob le Feber; Jaap van Pelt; Wim Rutten

doi:10.1109/IEMBS.2007.4352960

Latency dependent development of related firing patterns of cultured cortical neurons

Jakob le Feber, Jaap van Pelt, Wim Rutten

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

3 Citations (Scopus)

5 Downloads (Pure)

Abstract

Networks of cortical neurons were grown over multi electrode arrays to enable simultaneous measurement of signals from multiple neurons. We described functional connectivity in these networks by relationships be¬tween individual electrodes, based on conditional firing probabilities. In this study we investigated periods in which the strength of a relation¬ship monotonously increased (strengthening) or decreased (weakening) during periods of 24 or 10 hours. We observed a slightly increased incidence of latencies up to 25 ms during strengthening, while these latencies rarely occurreded during weakening. Next, it appeared that relationships tended to strengthen more than average in periods with latencies in the range 5-30 ms, whereas strengthening was significantly less than average in latencies 40-65 ms.

Original language	Undefined
Title of host publication	29th annual international conference of the IEEE EMBS
Place of Publication	UK
Publisher	Institute of Physics (IOP)
Pages	3000-3003
Number of pages	4
ISBN (Print)	1-4244-0788-5
DOIs	https://doi.org/10.1109/IEMBS.2007.4352960
Publication status	Published - Aug 2007
Event	29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2007 - Convention Center, 'Cité Internationale', Lyon, France Duration: 23 Aug 2007 → 26 Aug 2017 Conference number: 29

Publication series

Name
Publisher	IOP Publishing
Number	Paper P-NS

Conference

Conference	29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2007
Abbreviated title	EMBC
Country/Territory	France
City	Lyon
Period	23/08/07 → 26/08/17

Keywords

BSS-Neurotechnology and cellular engineering
METIS-245768
EWI-11372
IR-62012

Access to Document

10.1109/IEMBS.2007.4352960

http://eprints.eemcs.utwente.nl/secure2/11372/01/lyon07.pdf

Cite this

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title = "Latency dependent development of related firing patterns of cultured cortical neurons",

abstract = "Networks of cortical neurons were grown over multi electrode arrays to enable simultaneous measurement of signals from multiple neurons. We described functional connectivity in these networks by relationships be¬tween individual electrodes, based on conditional firing probabilities. In this study we investigated periods in which the strength of a relation¬ship monotonously increased (strengthening) or decreased (weakening) during periods of 24 or 10 hours. We observed a slightly increased incidence of latencies up to 25 ms during strengthening, while these latencies rarely occurreded during weakening. Next, it appeared that relationships tended to strengthen more than average in periods with latencies in the range 5-30 ms, whereas strengthening was significantly less than average in latencies 40-65 ms.",

keywords = "BSS-Neurotechnology and cellular engineering, METIS-245768, EWI-11372, IR-62012",

author = "{le Feber}, Jakob and {van Pelt}, Jaap and Wim Rutten",

year = "2007",

month = aug,

doi = "10.1109/IEMBS.2007.4352960",

language = "Undefined",

isbn = "1-4244-0788-5",

publisher = "Institute of Physics (IOP)",

number = "Paper P-NS",

pages = "3000--3003",

booktitle = "29th annual international conference of the IEEE EMBS",

address = "United Kingdom",

note = "29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2007 ; Conference date: 23-08-2007 Through 26-08-2017",

}

le Feber, J, van Pelt, J & Rutten, W 2007, Latency dependent development of related firing patterns of cultured cortical neurons. in 29th annual international conference of the IEEE EMBS. Institute of Physics (IOP), UK, pp. 3000-3003, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2007, Lyon, France, 23/08/07. https://doi.org/10.1109/IEMBS.2007.4352960

TY - GEN

T1 - Latency dependent development of related firing patterns of cultured cortical neurons

AU - le Feber, Jakob

AU - van Pelt, Jaap

AU - Rutten, Wim

N1 - Conference code: 29

PY - 2007/8

Y1 - 2007/8

N2 - Networks of cortical neurons were grown over multi electrode arrays to enable simultaneous measurement of signals from multiple neurons. We described functional connectivity in these networks by relationships be¬tween individual electrodes, based on conditional firing probabilities. In this study we investigated periods in which the strength of a relation¬ship monotonously increased (strengthening) or decreased (weakening) during periods of 24 or 10 hours. We observed a slightly increased incidence of latencies up to 25 ms during strengthening, while these latencies rarely occurreded during weakening. Next, it appeared that relationships tended to strengthen more than average in periods with latencies in the range 5-30 ms, whereas strengthening was significantly less than average in latencies 40-65 ms.

AB - Networks of cortical neurons were grown over multi electrode arrays to enable simultaneous measurement of signals from multiple neurons. We described functional connectivity in these networks by relationships be¬tween individual electrodes, based on conditional firing probabilities. In this study we investigated periods in which the strength of a relation¬ship monotonously increased (strengthening) or decreased (weakening) during periods of 24 or 10 hours. We observed a slightly increased incidence of latencies up to 25 ms during strengthening, while these latencies rarely occurreded during weakening. Next, it appeared that relationships tended to strengthen more than average in periods with latencies in the range 5-30 ms, whereas strengthening was significantly less than average in latencies 40-65 ms.

KW - BSS-Neurotechnology and cellular engineering

KW - METIS-245768

KW - EWI-11372

KW - IR-62012

U2 - 10.1109/IEMBS.2007.4352960

DO - 10.1109/IEMBS.2007.4352960

M3 - Conference contribution

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BT - 29th annual international conference of the IEEE EMBS

PB - Institute of Physics (IOP)

CY - UK

T2 - 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2007

Y2 - 23 August 2007 through 26 August 2017

ER -