Left ventricular force-velocity relations measured from quick volume changes

Piet Schiereck, H.B.K. Boom

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Abstract

Left ventricles of rabbit hearts were subjected to series of quick volume releases (QVR) — taking placw within 6 ms — applied at fixed times in the cardiac cycle. The hearts were paced artificially and allowed to contract isovolumically. The QVR was used as a tool for realizing predetermined pressure values at any time during the ascending limb of the intra-ventricular pressure curve. Any desired pressure could be attained by suitable choice of the QVR amplitude. By relatingdP/dt values occuring immediately after the QVR to the pressure attained by the QVR for different QVR amplitudes, instantaneousdP/dt relations were obtained. Time effects on these relations were studied by repeating the QVR series with increasing amplitudes at different but constant times. Influences of volume and contractile state were examined by varying end diastolic pressure (EDP) and the perfusate [Ca2+]. The data were fitted with adP/dt-P relation derived from the Hill equation using a simple geometric model of the ventricle and a two element model of the myocardium. The experimental relations were described adequately by the model. The parameters in the Hill equation estimated for heart muscle were compared to those previously reported on heart muscle experiments. Parameter values obtained were:a/F0: 0.001–1.3;F0 (mean maximal force forVCE=0): 12.2-3.5 N;b: 1.7–13.2 cm/s.F0 rises at the beginning of systole and shows a plateau from ca. 60–100% time of peak pressure. This time course was influenced by changes in EDP and [Ca2+]. Parameterb exhibits a time course comparable to that of ventricular pressure. It was not influenced by EDP changes and only slightly increased by an increase in [Ca2+].
Original languageUndefined
Pages (from-to)251-258
JournalPflügers Archiv : European journal of physiology
Volume379
Issue number3
DOIs
Publication statusPublished - 1979

Keywords

  • Quick volume release
  • Force-velocity relation
  • Ventricular model
  • Left ventricle
  • IR-85631
  • Hill equation
  • Active state

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