Localisation Of The Subthalamic Nucleus In Parkinson’s Disease with Neural Beta and Gamma Activity of Local Field Potentials

Daphne Zwartjes; Rick Schuurman; Rens Verhagen; Ciska Heida; Fiorella Contarino; Rob de Bie; Pepijn van den Munckhof; Hubert Martens; Peter Veltink; Lo Bour

doi:10.1159/000351783

Abstract

Introduction: To refine the MRI-based target during DBS surgery, microelectrode recordings (MER) are often performed to detect target-specific single unit activity. This requires additional recording time and increases the risk for haemorrhage. In the future it may therefore be relevant to be able to determine the implantable lead's position based on local field potential (LFP) recordings from the lead itself which reflect activity of a larger neural population. This study aims to evaluate the nature of oscillatory activity in the subthalamic nucleus (STN) by means of intraoperative LFP-recordings, its relationship with microelectrode recordings and its potential use to locate the STN and its sensorimotor sub-area in patients with Parkinson’s disease during deep brain stimulation (DBS) surgery.

Methods: 25 patients with Parkinson’s disease are included in this study. MER and LFPs are recorded every 0.5 mm from multiple microelectrodes during DBS surgery in 48 STNs. A novel optimization approach to map the measurement points on an atlas STN based on the MER properties is used to enable a detailed spatial representation of these points. Power and coherence in different LFP frequencies at all points are assessed in reference to the point's location inside or outside the STN and its sensorimotor sub-area.

Results: Coherence between LFPs and the envelope of spiking activity significantly increases when entering the STN. There is also a pronounced increase in the LFP power in the gamma band, which persists throughout the entire STN in 100% of the cases. In 70% of the cases LFPs have a significantly higher power in the high beta frequency band in the sensorimotor STN, defined by the mapping algorithm, compared to the non-sensorimotor STN.

Conclusions: LFP gamma oscillations provide a useful tool for locating the STN intraoperatively and LFP beta oscillations can become useful to discriminate the sensorimotor area within the STN.

Original language	English
Pages (from-to)	153-153
Number of pages	1
Journal	Stereotactic and functional neurosurgery
Volume	91
Issue number	Suppl. 1
DOIs	https://doi.org/10.1159/000351783
Publication status	Published - 2013
Event	16th Quadrennial Meeting of World Society for Stereotactic and Functional Neurosurgery, WSSFN 2013 - Hotel NIkko Tokyo, Tokyo, Japan Duration: 27 May 2013 → 30 May 2013 Conference number: 16

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10.1159/000351783

1 Abstract

Localisation of the subthalamic nucleus in Parkinson's disease with neural beta and gamma activity of local field potentials
Verhagen, R., Zwartjes, D. G. M., Heida, T., Contarino, M. F., de Bie, R. M. A., van den Munckhof, P., Schuurman, P. R., Martens, H. C. F., Veltink, P. H. & Bour, L. J., 2013, p. S455-S455. 1 p.
Research output: Contribution to conference › Abstract › Academic

Cite this

Zwartjes, D., Schuurman, R., Verhagen, R., Heida, C., Contarino, F., de Bie, R., van den Munckhof, P., Martens, H., Veltink, P., & Bour, L. (2013). Localisation Of The Subthalamic Nucleus In Parkinson’s Disease with Neural Beta and Gamma Activity of Local Field Potentials. Stereotactic and functional neurosurgery, 91(Suppl. 1), 153-153. https://doi.org/10.1159/000351783

@article{88c4e5a6b75345ff962af6ac75f36b4c,

title = "Localisation Of The Subthalamic Nucleus In Parkinson{\textquoteright}s Disease with Neural Beta and Gamma Activity of Local Field Potentials",

abstract = "Introduction: To refine the MRI-based target during DBS surgery, microelectrode recordings (MER) are often performed to detect target-specific single unit activity. This requires additional recording time and increases the risk for haemorrhage. In the future it may therefore be relevant to be able to determine the implantable lead's position based on local field potential (LFP) recordings from the lead itself which reflect activity of a larger neural population. This study aims to evaluate the nature of oscillatory activity in the subthalamic nucleus (STN) by means of intraoperative LFP-recordings, its relationship with microelectrode recordings and its potential use to locate the STN and its sensorimotor sub-area in patients with Parkinson{\textquoteright}s disease during deep brain stimulation (DBS) surgery.Methods: 25 patients with Parkinson{\textquoteright}s disease are included in this study. MER and LFPs are recorded every 0.5 mm from multiple microelectrodes during DBS surgery in 48 STNs. A novel optimization approach to map the measurement points on an atlas STN based on the MER properties is used to enable a detailed spatial representation of these points. Power and coherence in different LFP frequencies at all points are assessed in reference to the point's location inside or outside the STN and its sensorimotor sub-area.Results: Coherence between LFPs and the envelope of spiking activity significantly increases when entering the STN. There is also a pronounced increase in the LFP power in the gamma band, which persists throughout the entire STN in 100% of the cases. In 70% of the cases LFPs have a significantly higher power in the high beta frequency band in the sensorimotor STN, defined by the mapping algorithm, compared to the non-sensorimotor STN.Conclusions: LFP gamma oscillations provide a useful tool for locating the STN intraoperatively and LFP beta oscillations can become useful to discriminate the sensorimotor area within the STN.",

author = "Daphne Zwartjes and Rick Schuurman and Rens Verhagen and Ciska Heida and Fiorella Contarino and {de Bie}, Rob and {van den Munckhof}, Pepijn and Hubert Martens and Peter Veltink and Lo Bour",

year = "2013",

doi = "10.1159/000351783",

language = "English",

volume = "91",

pages = "153--153",

journal = "Stereotactic and functional neurosurgery",

issn = "1011-6125",

publisher = "Karger",

number = "Suppl. 1",

note = "16th Quadrennial Meeting of World Society for Stereotactic and Functional Neurosurgery, WSSFN 2013, WSSFN ; Conference date: 27-05-2013 Through 30-05-2013",

}

Zwartjes, D, Schuurman, R, Verhagen, R, Heida, C, Contarino, F, de Bie, R, van den Munckhof, P, Martens, H, Veltink, P & Bour, L 2013, 'Localisation Of The Subthalamic Nucleus In Parkinson’s Disease with Neural Beta and Gamma Activity of Local Field Potentials', Stereotactic and functional neurosurgery, vol. 91, no. Suppl. 1, pp. 153-153. https://doi.org/10.1159/000351783

TY - JOUR

T1 - Localisation Of The Subthalamic Nucleus In Parkinson’s Disease with Neural Beta and Gamma Activity of Local Field Potentials

AU - Zwartjes, Daphne

AU - Schuurman, Rick

AU - Verhagen, Rens

AU - Heida, Ciska

AU - Contarino, Fiorella

AU - de Bie, Rob

AU - van den Munckhof, Pepijn

AU - Martens, Hubert

AU - Veltink, Peter

AU - Bour, Lo

N1 - Conference code: 16

PY - 2013

Y1 - 2013

N2 - Introduction: To refine the MRI-based target during DBS surgery, microelectrode recordings (MER) are often performed to detect target-specific single unit activity. This requires additional recording time and increases the risk for haemorrhage. In the future it may therefore be relevant to be able to determine the implantable lead's position based on local field potential (LFP) recordings from the lead itself which reflect activity of a larger neural population. This study aims to evaluate the nature of oscillatory activity in the subthalamic nucleus (STN) by means of intraoperative LFP-recordings, its relationship with microelectrode recordings and its potential use to locate the STN and its sensorimotor sub-area in patients with Parkinson’s disease during deep brain stimulation (DBS) surgery.Methods: 25 patients with Parkinson’s disease are included in this study. MER and LFPs are recorded every 0.5 mm from multiple microelectrodes during DBS surgery in 48 STNs. A novel optimization approach to map the measurement points on an atlas STN based on the MER properties is used to enable a detailed spatial representation of these points. Power and coherence in different LFP frequencies at all points are assessed in reference to the point's location inside or outside the STN and its sensorimotor sub-area.Results: Coherence between LFPs and the envelope of spiking activity significantly increases when entering the STN. There is also a pronounced increase in the LFP power in the gamma band, which persists throughout the entire STN in 100% of the cases. In 70% of the cases LFPs have a significantly higher power in the high beta frequency band in the sensorimotor STN, defined by the mapping algorithm, compared to the non-sensorimotor STN.Conclusions: LFP gamma oscillations provide a useful tool for locating the STN intraoperatively and LFP beta oscillations can become useful to discriminate the sensorimotor area within the STN.

AB - Introduction: To refine the MRI-based target during DBS surgery, microelectrode recordings (MER) are often performed to detect target-specific single unit activity. This requires additional recording time and increases the risk for haemorrhage. In the future it may therefore be relevant to be able to determine the implantable lead's position based on local field potential (LFP) recordings from the lead itself which reflect activity of a larger neural population. This study aims to evaluate the nature of oscillatory activity in the subthalamic nucleus (STN) by means of intraoperative LFP-recordings, its relationship with microelectrode recordings and its potential use to locate the STN and its sensorimotor sub-area in patients with Parkinson’s disease during deep brain stimulation (DBS) surgery.Methods: 25 patients with Parkinson’s disease are included in this study. MER and LFPs are recorded every 0.5 mm from multiple microelectrodes during DBS surgery in 48 STNs. A novel optimization approach to map the measurement points on an atlas STN based on the MER properties is used to enable a detailed spatial representation of these points. Power and coherence in different LFP frequencies at all points are assessed in reference to the point's location inside or outside the STN and its sensorimotor sub-area.Results: Coherence between LFPs and the envelope of spiking activity significantly increases when entering the STN. There is also a pronounced increase in the LFP power in the gamma band, which persists throughout the entire STN in 100% of the cases. In 70% of the cases LFPs have a significantly higher power in the high beta frequency band in the sensorimotor STN, defined by the mapping algorithm, compared to the non-sensorimotor STN.Conclusions: LFP gamma oscillations provide a useful tool for locating the STN intraoperatively and LFP beta oscillations can become useful to discriminate the sensorimotor area within the STN.

U2 - 10.1159/000351783

DO - 10.1159/000351783

M3 - Meeting Abstract

SN - 1011-6125

VL - 91

SP - 153

EP - 153

JO - Stereotactic and functional neurosurgery

JF - Stereotactic and functional neurosurgery

IS - Suppl. 1

T2 - 16th Quadrennial Meeting of World Society for Stereotactic and Functional Neurosurgery, WSSFN 2013

Y2 - 27 May 2013 through 30 May 2013

ER -

Localisation Of The Subthalamic Nucleus In Parkinson’s Disease with Neural Beta and Gamma Activity of Local Field Potentials

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Localisation of the subthalamic nucleus in Parkinson's disease with neural beta and gamma activity of local field potentials

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