Localization Study of Co-Phthalocyanines in Cells by Raman Micro(spectro)scopy

S.Y. Arzhantsev, S.Y. Arzhantsev, A.Y. Chikishev, A.Y. Chikishev, N.I. Koroteev, Jan Greve, Cornelis Otto, N.M. Sijtsema

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Abstract

An investigation of intracellular localization of Co-phthalocyanines is reported. The Raman images of K562 cells stained with phthalocyanine were acquired. To understand the peculiarities of the Raman images, measurements were performed at different z-axis positions. The intracellular concentration of phthalocyanine was estimated. A colocalization study was carried out using the fluorescence probes FITC-dextran and acridine orange by means of Raman and fluorescence microscopy. Partial colocalization with both probes was revealed.
Original languageUndefined
Pages (from-to)205-208
Number of pages4
JournalJournal of raman spectroscopy
Volume30
Issue number3
Publication statusPublished - 1999

Keywords

  • METIS-128412
  • IR-71537

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