Abstract
α-Synuclein is abundantly present in Lewy bodies, characteristic of Parkinson’s disease. Its exact physiological role has yet to be determined, but mitochondrial membrane binding is suspected to be a key aspect of its function. Electron paramagnetic resonance spectroscopy in combination with site-directed spin labeling allowed for a locally resolved analysis of the protein–membrane binding affinity for artificial phospholipid membranes, supported by a study of binding to isolated mitochondria. The data reveal that the binding affinity of the N-terminus is nonuniform
Original language | Undefined |
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Pages (from-to) | 3960-3962 |
Number of pages | 3 |
Journal | Biochemistry (USA) |
Volume | 51 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- METIS-289434
- IR-84730