Long-term cost–effectiveness of Oncotype DX® versus current clinical practice from a Dutch cost perspective

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This study analyzes the incremental cost–effectiveness of Oncotype DX® testing to support adjuvant chemotherapy recommendations, versus current clinical practice, for patients with estrogen receptor-positive (ER+), node-negative or micrometastatic (pN1mic) early-stage breast cancer in The Netherlands. Methods: Markov model projecting distant recurrence, survival, quality-adjusted life years (QALYs) and healthcare costs over a 30-year time horizon. Results: Oncotype DX was projected to increase QALYs by 0.11 (0.07–0.58) and costs with €1236 (range: -€142–€1236) resulting in an incremental cost–effectiveness ratio of €11,236/QALY under the most conservative scenario. Conclusion: Reallocation of adjuvant chemotherapy based on Oncotype DX testing is most likely a cost-effective use of scarce resources, improving long-term survival and QALYs at marginal or lower costs
Original languageEnglish
Pages (from-to)433-445
JournalJournal of comparative effectiveness research
Issue number5
Publication statusPublished - 15 Apr 2015



  • METIS-311572
  • IR-97101

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