Long-term Effect of Injection Treatment for Osteoarthritis in the Knee by Orthokin Autologous Conditioned Serum

Danial Zarringam, Joris E. J. Bekkers, Daniel B. F. Saris (Corresponding Author)

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
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Orthokin is an intra-articular autologous conditioned serum (ACS). Its use might have a beneficial biological effect on pain and function of osteoarthritis in the knee. However, earlier studies lack any consensus on its clinical application and disease modifying effect.

The aim of this study was to investigate the long-term effect of Orthokin injection treatment on prevention of surgical treatment for end-stage knee osteoarthritis.
Study Design

Prospective cohort study.

Patients of the previously published Orthokin cohort were contacted to determine whether any intra-articular surgical intervention or osteotomy of the study knee had taken place during the past decade. A log-rank test was performed to evaluate the differences in the survival distribution for the 2 types of intervention: Orthokin versus placebo.

The survival distributions for the 2 interventions were not statistically significantly different, χ2(1) = 2.069, P = 0.150. After 7.5 ± 3.9 years, 46.3% of the placebo and 40.3% of the Orthokin group had been treated surgically.

The use of Orthokin in knee osteoarthritis patients did not result in a delay regarding surgical treatment.

Clinical Relevance

The intra-articular use of Orthokin does not seem to prevent or delay surgical intervention at 10 years after treatment for end-stage knee osteoarthritis.
Original languageEnglish
Pages (from-to)140-145
Number of pages6
Issue number2
Publication statusPublished - 1 Apr 2018
Externally publishedYes


  • UT-Hybrid-D
  • Orthokin
  • interleukin-1
  • disease-modifying osteoarthritis drugs
  • placebo
  • osteoarthritis


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