Long-term multielectrode registration of neuronal firing activity from rat cerebral cortex tissue in vitro

Jaap van Pelt, Pieter Wolters, Dora van Veen, Johan Bomer, Wim Rutten, Hans Overdijk, Ger J.A. Ramakers

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    4 Citations (Scopus)

    Abstract

    Activity-dependent processes are involved in neurite outgrowth and synaptogenesis. We expect that during neural network formation neuronal morphogenesis and synaptic connectivity are reciprocally dependent on the emerging bioelectric activity in the network. We want to study whether and how bioelectric activity is involved in the formation of network structure. A multielectrode recording facility has been constructed for the long-term registration of action potentials of individual neurons during network development in both organotypic and dissociated rat cerebral cortex tissue cultures. Long-term recordings of' action potentials with good signal-to-noise ratios have been obtained. Experiments to correlate these activity levels with quantitative data on neuronal morphological development are in progress. Uncorrelated periodic fluctuations at a time scale of about ten minutes have been observed.
    Original languageEnglish
    Title of host publicationConference Proceedings 1996 IEEE Engineering in Medicine and Biology Society 18th Annual International Conference
    PublisherIEEE Engineering in Medicine and Biology Society
    Number of pages2
    Volume1
    ISBN (Electronic)90-9010005-9 (CD-ROM)
    ISBN (Print)9780780338111, 9780780338128, 9780780338135, 9789090100050
    Publication statusPublished - 31 Oct 1996
    Event18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996: Bridging Disciplines for Biomedicine - Amsterdam, Netherlands
    Duration: 31 Oct 19963 Nov 1996
    Conference number: 18

    Conference

    Conference18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 1996
    Abbreviated titleEMBC
    Country/TerritoryNetherlands
    CityAmsterdam
    Period31/10/963/11/96

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