Long-term prognostic value of quantitative myocardial perfusion in patients with chest pain and normal coronary arteries

Andrea G. Monroy-Gonzalez*, R. A. Tio, J. C. de Groot, H. H. Boersma, N. H. Prakken, M. J.L. De Jongste, E. Alexanderson-Rosas, R. H.J.A. Slart

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
2 Downloads (Pure)

Abstract

Background: Patients with chest pain and no obstructive coronary artery disease have shown a high incidence of major adverse cardiovascular events (MACE). We evaluated the role of absolute myocardial perfusion quantification in predicting all-cause mortality and MACE during long-term follow-up in this group of patients. Methods: We studied 79 patients who underwent Nitrogen-13 ammonia PET for quantification of global myocardial blood flow (MBF) and myocardial flow reserve (MFR) due to suspected impaired myocardial perfusion. Patients with coronary artery disease (i.e., > 30% stenosis in one or more coronary arteries) were excluded. We assessed all-cause mortality and MACE. MACE was defined as the composite incidence of death, myocardial infarction (MI), or hospitalization due to heart failure. Results: Median follow-up was 8 (IQR: 3-14) years. Univariate Cox regression showed that only MFR (P = 0.01) was a predictor of all-cause mortality. Univariate Cox regression analysis showed that both MFR and Stress MBF were predictors of the composite endpoint of MACE (P < 0.001 and P = 0.01, respectively). Conclusion: Quantitative assessment of myocardial perfusion may predict all-cause mortality and MACE in patients with chest pain and normal coronary arteries in the long-term follow-up.

Original languageEnglish
Pages (from-to)1844-1852
Number of pages9
JournalJournal of nuclear cardiology
Volume26
Issue number6
DOIs
Publication statusPublished - 1 Dec 2019

Keywords

  • Diagnostic and prognostic application
  • Microvascular dysfunction
  • Myocardial blood flow
  • PET

Fingerprint Dive into the research topics of 'Long-term prognostic value of quantitative myocardial perfusion in patients with chest pain and normal coronary arteries'. Together they form a unique fingerprint.

Cite this