# Loss of gas from echogenic liposomes exposed to pulsed ultrasound

J.L. Raymond, Y. Luan, T. Peng, S.L. Huang, D.D. McPherson, Michel Versluis, N. de Jong, C.K. Holland

9 Citations (Scopus)

## Abstract

The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, $\dot{{R}}$  /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency.
Original language English 8321-8339 18 Physics in medicine and biology 61 23 https://doi.org/10.1088/0031-9155/61/23/8321 Published - 2016

• METIS-322019
• IR-104622

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