Loss of gas from echogenic liposomes exposed to pulsed ultrasound

J.L. Raymond, Y. Luan, T. Peng, S.L. Huang, D.D. McPherson, Michel Versluis, N. de Jong, C.K. Holland

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, $\dot{{R}}$  /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency.
Original languageEnglish
Pages (from-to)8321-8339
Number of pages18
JournalPhysics in medicine and biology
Volume61
Issue number23
DOIs
Publication statusPublished - 2016

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Liposomes
Gases
Microbubbles
Vibration
Acoustics
Dilatation
Ultrasonic Waves
Pressure

Keywords

  • METIS-322019
  • IR-104622

Cite this

Raymond, J. L., Luan, Y., Peng, T., Huang, S. L., McPherson, D. D., Versluis, M., ... Holland, C. K. (2016). Loss of gas from echogenic liposomes exposed to pulsed ultrasound. Physics in medicine and biology, 61(23), 8321-8339. https://doi.org/10.1088/0031-9155/61/23/8321
Raymond, J.L. ; Luan, Y. ; Peng, T. ; Huang, S.L. ; McPherson, D.D. ; Versluis, Michel ; de Jong, N. ; Holland, C.K. / Loss of gas from echogenic liposomes exposed to pulsed ultrasound. In: Physics in medicine and biology. 2016 ; Vol. 61, No. 23. pp. 8321-8339.
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abstract = "The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35{\%}) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, $\dot{{R}}$  /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency.",
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Raymond, JL, Luan, Y, Peng, T, Huang, SL, McPherson, DD, Versluis, M, de Jong, N & Holland, CK 2016, 'Loss of gas from echogenic liposomes exposed to pulsed ultrasound', Physics in medicine and biology, vol. 61, no. 23, pp. 8321-8339. https://doi.org/10.1088/0031-9155/61/23/8321

Loss of gas from echogenic liposomes exposed to pulsed ultrasound. / Raymond, J.L.; Luan, Y.; Peng, T.; Huang, S.L.; McPherson, D.D.; Versluis, Michel; de Jong, N.; Holland, C.K.

In: Physics in medicine and biology, Vol. 61, No. 23, 2016, p. 8321-8339.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Loss of gas from echogenic liposomes exposed to pulsed ultrasound

AU - Raymond, J.L.

AU - Luan, Y.

AU - Peng, T.

AU - Huang, S.L.

AU - McPherson, D.D.

AU - Versluis, Michel

AU - de Jong, N.

AU - Holland, C.K.

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N2 - The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, $\dot{{R}}$  /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency.

AB - The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation nucleated by ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6 MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35%) ultra- high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, $\dot{{R}}$  /R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g. by tuning the size distribution or the excitation frequency.

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