Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons

Anna Petoukhova, Wiendelt Steenbergen, F.F.M. de Mul

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

We report here first results of measurements of the pathlength distribution of scattered photons by low- coherence Doppler interferometry. Laser Doppler Flowmetry (LDF) is used to non-invasively monitor the blood micro circulation in biological tissue. On the other hand, the LDF response is also affected by the optical properties of the tissue itself, which complicates the problem of the exact evaluation of the blood perfusion. In a scattering medium like skin photons travel along different paths of variable length. The longer the pathlength, the higher the change for the photon to be scattered by a blood cell. An aqueous suspension of Intralipid is used to mimic the most important properties of the skin. Using a free beam Michelson interferometer we measure the AC component of the intensity of the pattern formed by interfering the scattered light with a coherent component from the reference channel. In each measurement the mirror in the reference channel is kept fixed while the AC component arises due to the Doppler effect in light scattered by the micro-particles experiencing Brownian motion. The pathlength distribution is extracted from the dependence of the detected signal on the reference mirror position.
Original languageEnglish
Title of host publicationCoherence Domain Optical Methods in Biomedical Science and Clinical Applications IV
PublisherSPIE
Pages121-128
Number of pages8
ISBN (Print)0-8194-3531-7
DOIs
Publication statusPublished - 15 Jun 2000

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume3915
ISSN (Print)0277-786X

Fingerprint

interferometry
blood
alternating current
photons
mirrors
blood cells
Doppler effect
Michelson interferometers
travel
lasers
optical properties
evaluation
scattering

Keywords

  • METIS-130610
  • IR-96458

Cite this

Petoukhova, A., Steenbergen, W., & de Mul, F. F. M. (2000). Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons. In Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV (pp. 121-128). (Proceedings of SPIE; Vol. 3915). SPIE. https://doi.org/10.1117/12.384148
Petoukhova, Anna ; Steenbergen, Wiendelt ; de Mul, F.F.M. / Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons. Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV. SPIE, 2000. pp. 121-128 (Proceedings of SPIE).
@inproceedings{9d7b70e5d37341b882f68704b9d28146,
title = "Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons",
abstract = "We report here first results of measurements of the pathlength distribution of scattered photons by low- coherence Doppler interferometry. Laser Doppler Flowmetry (LDF) is used to non-invasively monitor the blood micro circulation in biological tissue. On the other hand, the LDF response is also affected by the optical properties of the tissue itself, which complicates the problem of the exact evaluation of the blood perfusion. In a scattering medium like skin photons travel along different paths of variable length. The longer the pathlength, the higher the change for the photon to be scattered by a blood cell. An aqueous suspension of Intralipid is used to mimic the most important properties of the skin. Using a free beam Michelson interferometer we measure the AC component of the intensity of the pattern formed by interfering the scattered light with a coherent component from the reference channel. In each measurement the mirror in the reference channel is kept fixed while the AC component arises due to the Doppler effect in light scattered by the micro-particles experiencing Brownian motion. The pathlength distribution is extracted from the dependence of the detected signal on the reference mirror position.",
keywords = "METIS-130610, IR-96458",
author = "Anna Petoukhova and Wiendelt Steenbergen and {de Mul}, F.F.M.",
year = "2000",
month = "6",
day = "15",
doi = "10.1117/12.384148",
language = "English",
isbn = "0-8194-3531-7",
series = "Proceedings of SPIE",
publisher = "SPIE",
pages = "121--128",
booktitle = "Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV",
address = "United States",

}

Petoukhova, A, Steenbergen, W & de Mul, FFM 2000, Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons. in Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV. Proceedings of SPIE, vol. 3915, SPIE, pp. 121-128. https://doi.org/10.1117/12.384148

Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons. / Petoukhova, Anna; Steenbergen, Wiendelt; de Mul, F.F.M.

Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV. SPIE, 2000. p. 121-128 (Proceedings of SPIE; Vol. 3915).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons

AU - Petoukhova, Anna

AU - Steenbergen, Wiendelt

AU - de Mul, F.F.M.

PY - 2000/6/15

Y1 - 2000/6/15

N2 - We report here first results of measurements of the pathlength distribution of scattered photons by low- coherence Doppler interferometry. Laser Doppler Flowmetry (LDF) is used to non-invasively monitor the blood micro circulation in biological tissue. On the other hand, the LDF response is also affected by the optical properties of the tissue itself, which complicates the problem of the exact evaluation of the blood perfusion. In a scattering medium like skin photons travel along different paths of variable length. The longer the pathlength, the higher the change for the photon to be scattered by a blood cell. An aqueous suspension of Intralipid is used to mimic the most important properties of the skin. Using a free beam Michelson interferometer we measure the AC component of the intensity of the pattern formed by interfering the scattered light with a coherent component from the reference channel. In each measurement the mirror in the reference channel is kept fixed while the AC component arises due to the Doppler effect in light scattered by the micro-particles experiencing Brownian motion. The pathlength distribution is extracted from the dependence of the detected signal on the reference mirror position.

AB - We report here first results of measurements of the pathlength distribution of scattered photons by low- coherence Doppler interferometry. Laser Doppler Flowmetry (LDF) is used to non-invasively monitor the blood micro circulation in biological tissue. On the other hand, the LDF response is also affected by the optical properties of the tissue itself, which complicates the problem of the exact evaluation of the blood perfusion. In a scattering medium like skin photons travel along different paths of variable length. The longer the pathlength, the higher the change for the photon to be scattered by a blood cell. An aqueous suspension of Intralipid is used to mimic the most important properties of the skin. Using a free beam Michelson interferometer we measure the AC component of the intensity of the pattern formed by interfering the scattered light with a coherent component from the reference channel. In each measurement the mirror in the reference channel is kept fixed while the AC component arises due to the Doppler effect in light scattered by the micro-particles experiencing Brownian motion. The pathlength distribution is extracted from the dependence of the detected signal on the reference mirror position.

KW - METIS-130610

KW - IR-96458

U2 - 10.1117/12.384148

DO - 10.1117/12.384148

M3 - Conference contribution

SN - 0-8194-3531-7

T3 - Proceedings of SPIE

SP - 121

EP - 128

BT - Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV

PB - SPIE

ER -

Petoukhova A, Steenbergen W, de Mul FFM. Low-coherence Doppler interferometry to determine pathlength distribution of multiple-scattered photons. In Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV. SPIE. 2000. p. 121-128. (Proceedings of SPIE). https://doi.org/10.1117/12.384148