Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure

Alex J. Thompson, Skylar Buchan, Benjamin Carr, Clinton Poling, McKenzie Hayes, Uditha Piyumindri Fernando, Andreas Kaesler, Peter C. Schlanstein, Felix Hesselmann, Jutta Arens, Joseph Potkay, Alvaro Rojas-Pena, Robert H. Bartlett, Ronald B. Hirschl

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Children with end-stage lung failure awaiting lung transplant would benefit from improvements in artificial lung technology allowing for wearable pulmonary support as a bridge-to-transplant therapy. In this work, we designed, fabricated, and tested the Pediatric MLung-a dual-inlet hollow fiber artificial lung based on concentric gating, which has a rated flow of 1 L/min, and a pressure drop of 25 mm Hg at rated flow. This device and future iterations of the current design are designed to relieve pulmonary arterial hypertension, provide pulmonary support, reduce ventilator-associated injury, and allow for more effective therapy of patients with end-stage lung disease, including bridge-to-transplant treatment. ASAIO Journal 2020; 66:423-432.

Original languageEnglish
Pages (from-to)423 - 432
Number of pages10
JournalASAIO Journal
Volume66
Issue number4
Early online dateJun 2019
DOIs
Publication statusPublished - Apr 2020
Externally publishedYes

Keywords

  • Extracorporeal life support
  • Hollow fiber oxygenator
  • Wearable artificial lung
  • extracorporeal life support
  • wearable artificial lung
  • hollow fiber oxygenator

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  • Cite this

    Thompson, A. J., Buchan, S., Carr, B., Poling, C., Hayes, M., Fernando, U. P., ... Hirschl, R. B. (2020). Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure. ASAIO Journal, 66(4), 423 - 432. https://doi.org/10.1097/MAT.0000000000001018