Lysozyme self-assembles into amyloid networks that support cartilage tissue formation

Research output: Contribution to journalMeeting AbstractOther research output

12 Citations (Scopus)
59 Downloads (Pure)

Abstract

Purpose: No cure is available for repair of damaged cartilage. Once damaged, cartilage will continue to degenerate, resulting in immobile and painful joints. Treatments are limited to symptom relief, while tissue engineering approaches fail to produce cartilage comparable to native articular cartilage in terms of strength and modulus. In this project, we investigated the use of self-assembling proteins as scaffold material for cartilage tissue engineering. These so-called amy-loid networks consist of amyloid fibrils forming physical cross-links. The fibrils self-assemble from proteins by forming inter-protein B-sheets.
Amyloid networks resemble the extracellular matrix of cartilage
since the strength and Young’s modulus of the fibrils is comparable to
those of collagen and the networks are hydrogels. We therefore
hypothesized that amyloid networks can be used as scaffold material for
cartilage tissue engineering.
Original languageEnglish
Article number794
Pages (from-to)S465
JournalOsteoarthritis and cartilage
Volume24
Issue numbersupplement 1
DOIs
Publication statusPublished - Apr 2016
Event2016 OARSI World Congress on Osteoarthrtis - Amsterdam RAI, Amsterdam, Netherlands
Duration: 31 Mar 20163 Apr 2016

Keywords

  • IR-103806
  • METIS-314882

Fingerprint Dive into the research topics of 'Lysozyme self-assembles into amyloid networks that support cartilage tissue formation'. Together they form a unique fingerprint.

  • Cite this