Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

Elsbeth G.B.M. Bossink*, Anke R. Vollertsen, Loes I. Segerink, Mathieu Odijk

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    Abstract

    Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.
    Original languageEnglish
    Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Place of PublicationBasel, Switzerland
    PublisherChemical and Biological Micro Systems Society
    Pages1664-1665
    Number of pages2
    Edition23
    ISBN (Electronic)978-1-7334190-0-0
    Publication statusPublished - 28 Oct 2019
    Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland
    Duration: 27 Oct 201931 Oct 2019
    Conference number: 23
    https://cbmsociety.org/microtas/microtas2019/

    Conference

    Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
    Abbreviated titleMicroTAS 2019
    CountrySwitzerland
    CityBasel
    Period27/10/1931/10/19
    Internet address

    Fingerprint

    Microfluidics
    Macros
    Pumps
    Fabrication
    Photoresists
    Switches
    System-on-chip

    Cite this

    Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.
    Bossink, Elsbeth G.B.M. ; Vollertsen, Anke R. ; Segerink, Loes I. ; Odijk, Mathieu . / Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. pp. 1664-1665
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    title = "Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications",
    abstract = "Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.",
    author = "Bossink, {Elsbeth G.B.M.} and Vollertsen, {Anke R.} and Segerink, {Loes I.} and Mathieu Odijk",
    year = "2019",
    month = "10",
    day = "28",
    language = "English",
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    booktitle = "23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences",
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    Bossink, EGBM, Vollertsen, AR, Segerink, LI & Odijk, M 2019, Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 edn, Chemical and Biological Micro Systems Society, Basel, Switzerland, pp. 1664-1665, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland, 27/10/19.

    Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. / Bossink, Elsbeth G.B.M.; Vollertsen, Anke R.; Segerink, Loes I.; Odijk, Mathieu .

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. p. 1664-1665.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    T1 - Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

    AU - Bossink, Elsbeth G.B.M.

    AU - Vollertsen, Anke R.

    AU - Segerink, Loes I.

    AU - Odijk, Mathieu

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    N2 - Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

    AB - Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

    M3 - Conference contribution

    SP - 1664

    EP - 1665

    BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

    PB - Chemical and Biological Micro Systems Society

    CY - Basel, Switzerland

    ER -

    Bossink EGBM, Vollertsen AR, Segerink LI, Odijk M. Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 ed. Basel, Switzerland: Chemical and Biological Micro Systems Society. 2019. p. 1664-1665