Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

Elsbeth G.B.M. Bossink; Anke R. Vollertsen; Loes I. Segerink; Mathieu  Odijk

Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

Elsbeth G.B.M. Bossink^*, Anke R. Vollertsen, Loes I. Segerink, Mathieu Odijk

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

Original language	English
Title of host publication	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of Publication	Basel, Switzerland
Publisher	Chemical and Biological Micro Systems Society
Pages	1664-1665
Number of pages	2
Edition	23
ISBN (Electronic)	978-1-7334190-0-0
Publication status	Published - 28 Oct 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23 https://cbmsociety.org/microtas/microtas2019/

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
Abbreviated title	MicroTAS 2019
Country	Switzerland
City	Basel
Period	27/10/19 → 31/10/19
Internet address	https://cbmsociety.org/microtas/microtas2019/

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Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.

Bossink, Elsbeth G.B.M. ; Vollertsen, Anke R. ; Segerink, Loes I. ; Odijk, Mathieu . / Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. pp. 1664-1665

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title = "Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications",

abstract = "Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.",

author = "Bossink, {Elsbeth G.B.M.} and Vollertsen, {Anke R.} and Segerink, {Loes I.} and Mathieu Odijk",

year = "2019",

month = "10",

day = "28",

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Bossink, EGBM, Vollertsen, AR , Segerink, LI & Odijk, M 2019, Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 edn, Chemical and Biological Micro Systems Society, Basel, Switzerland, pp. 1664-1665, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland, 27/10/19.

Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. / Bossink, Elsbeth G.B.M.; Vollertsen, Anke R.; Segerink, Loes I.; Odijk, Mathieu .

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. p. 1664-1665.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AU - Bossink, Elsbeth G.B.M.

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AU - Segerink, Loes I.

AU - Odijk, Mathieu

PY - 2019/10/28

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N2 - Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

AB - Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

M3 - Conference contribution

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EP - 1665

BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Micro Systems Society

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