Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.
|Title of host publication||23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Place of Publication||Basel, Switzerland|
|Publisher||Chemical and Biological Micro Systems Society|
|Number of pages||2|
|Publication status||Published - 28 Oct 2019|
|Event||23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland|
Duration: 27 Oct 2019 → 31 Oct 2019
Conference number: 23
|Conference||23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019|
|Abbreviated title||MicroTAS 2019|
|Period||27/10/19 → 31/10/19|
Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.