Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

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Abstract

Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.
Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of PublicationBasel, Switzerland
PublisherChemical and Biological Micro Systems Society
Pages1664-1665
Number of pages2
Edition23
ISBN (Electronic)978-1-7334190-0-0
Publication statusPublished - 28 Oct 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019
Conference number: 23
https://cbmsociety.org/microtas/microtas2019/

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
Abbreviated titleMicroTAS 2019
CountrySwitzerland
CityBasel
Period27/10/1931/10/19
Internet address

Fingerprint

Microfluidics
Macros
Pumps
Fabrication
Photoresists
Switches
System-on-chip

Cite this

Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.
Bossink, Elsbeth G.B.M. ; Vollertsen, Anke R. ; Segerink, Loes I. ; Odijk, Mathieu . / Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. pp. 1664-1665
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abstract = "Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.",
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Bossink, EGBM, Vollertsen, AR, Segerink, LI & Odijk, M 2019, Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. in 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 edn, Chemical and Biological Micro Systems Society, Basel, Switzerland, pp. 1664-1665, 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019, Basel, Switzerland, 27/10/19.

Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. / Bossink, Elsbeth G.B.M.; Vollertsen, Anke R.; Segerink, Loes I.; Odijk, Mathieu .

23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23. ed. Basel, Switzerland : Chemical and Biological Micro Systems Society, 2019. p. 1664-1665.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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T1 - Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

AU - Bossink, Elsbeth G.B.M.

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AU - Odijk, Mathieu

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N2 - Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

AB - Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.

M3 - Conference contribution

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BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

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Bossink EGBM, Vollertsen AR, Segerink LI, Odijk M. Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. 23 ed. Basel, Switzerland: Chemical and Biological Micro Systems Society. 2019. p. 1664-1665