Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications

Elsbeth G.B.M. Bossink*, Anke R. Vollertsen, Loes I. Segerink, Mathieu Odijk

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    Abstract

    Integrated microfluidic valves enable automated control in microfluidic systems as they can be applied for mixing, pumping, and compartmentalisation purposes. However, many organ-on-chip systems require channel dimensions in the range of hundreds of micrometres while the typical fabrication process for normally open micro valves requires a reflow photoresist which is not capable of achieving these dimensions. Here we show a mechanical macro valve, fabricated cleanroom-free by micromilling, closing and bridging a 400 μm high, 1000 μm wide channel. Furthermore, we use the valves to create an inlet switch and a peristaltic pump with a pumping rate of 2 μL/min.
    Original languageEnglish
    Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Place of PublicationBasel, Switzerland
    PublisherChemical and Biological Micro Systems Society
    Pages1664-1665
    Number of pages2
    Edition23
    ISBN (Electronic)978-1-7334190-0-0
    Publication statusPublished - 28 Oct 2019
    Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019 - Congress Center Basel, Basel, Switzerland
    Duration: 27 Oct 201931 Oct 2019
    Conference number: 23
    https://cbmsociety.org/microtas/microtas2019/

    Conference

    Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019
    Abbreviated titleMicroTAS 2019
    CountrySwitzerland
    CityBasel
    Period27/10/1931/10/19
    Internet address

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  • Cite this

    Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.