Magnetic control of potential microrobotic drug delivery systems: nanoparticles, magnetotactic bacteria and self-propelled microjets

I.S.M. Khalil, V. Magdanz, Stefan Sanchez, S. Sanchez, O.G. Schmidt, Leon Abelmann, Sarthak Misra

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

    29 Citations (Scopus)
    36 Downloads (Pure)

    Abstract

    Development of targeted drug delivery systems using magnetic microrobots increases the therapeutic indices of drugs. These systems have to be incorporated with precise motion controllers. We demonstrate closed-loop motion control of microrobots under the influence of controlled magnetic fields. Point-to-point motion control of a cluster of iron oxide nanoparticles (diameter of 250 nm) is achieved by pulling the cluster towards a reference position using magnetic field gradients. Magnetotactic bacterium (MTB) is controlled by orienting the magnetic fields towards a reference position. MTB with membrane length of 5 μm moves towards the reference position using the propulsion force generated by its flagella. Similarly, self-propelled microjet with length of 50 μm is controlled by directing the microjet towards a reference position by external magnetic torque. The microjet moves along the field lines using the thrust force generated by the ejecting oxygen bubbles from one of its ends. Our control system positions the cluster of nanoparticles, an MTB and a microjet at an average velocity of 190 μm/s, 28 μm/s, 90 μm/s and within an average region-of-convergence of 132 μm, 40 μm, 235 μm, respectively.
    Original languageUndefined
    Title of host publication35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2013)
    Place of PublicationOsaka, Japan
    PublisherIEEE RAS
    Pages5299-5302
    Number of pages4
    ISBN (Print)978-1-4577-0216-7
    Publication statusPublished - 3 Jul 2013
    Event35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
    Duration: 3 Jul 20137 Jul 2013
    Conference number: 35

    Publication series

    Name
    PublisherIEEE

    Conference

    Conference35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
    Abbreviated titleEMBC
    CountryJapan
    CityOsaka
    Period3/07/137/07/13

    Keywords

    • EWI-23444
    • IR-86517
    • METIS-297703

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