Magnetic drug delivery with FePd nanowires

Kirsten M. Pondman, Nathan D. Bunt, A. Wouter Maijenburg, Richard J.A. van Wezel, Uday Kishore, Leon Abelmann, Johan E. ten Elshof, Bennie ten Haken*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)
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Magnetic drug delivery is a promising method to target a drug to a diseased area while reducing negative side effects caused by systemic administration of drugs. In magnetic drug delivery a therapeutic agent is coupled to a magnetic nanoparticle. The particles are injected and at the target location withdrawn from blood flow by a magnetic field. In this study a FePd nanowire is developed with optimised properties for magnetic targeting. The nanowires have a high magnetic moment to reduce the field gradient needed to capture them with a magnet. The dimensions and the materials of the nanowire and coating are such that they are dispersable in aqueous media, non-cytotoxic, easily phagocytosed and not complement activating. This is established in several in-vitro tests with macrophage and endothelial cell lines. Along with the nanowires a magnet is designed, optimised for capture of the nanowires from the blood flow in the hind leg of a rat. The system is used in a pilot scale in-vivo experiment. No negative side effects from injection of the nanowires were found within the limited time span of the experiment. In this first pilot experiment no nanowires were found to be targeted by the magnet, or in the liver, kidneys or spleen, most likely the particles were removed during the fixation procedure.
Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalJournal of magnetism and magnetic materials
Publication statusPublished - 15 Apr 2015


  • Immune response
  • Magnetic drug delivery
  • Nanowire
  • Toxicity
  • 2023 OA procedure


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