Magnetic particles for ctc enrichment

Peng Liu; Pascal Jonkheijm; Leon W.M.M. Terstappen; Michiel Stevens

doi:10.3390/cancers12123525

Magnetic particles for ctc enrichment

Peng Liu, Pascal Jonkheijm, Leon W.M.M. Terstappen, Michiel Stevens^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

15 Citations (Scopus)

33 Downloads (Pure)

Abstract

Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.

Original language	English
Article number	3525
Pages (from-to)	1-26
Number of pages	26
Journal	Cancers
Volume	12
Issue number	12
DOIs	https://doi.org/10.3390/cancers12123525
Publication status	Published - Dec 2020

Keywords

CTC
Ferrofluids
Immunomagnetic separation
Magnetic nanoparticle
Non-specific binding
Positive enrichment
Rare cell detection

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10.3390/cancers12123525Licence: CC BY

Liu-2020-Magnetic-particles-for-ctc-enrichmeFinal published version, 6.2 MBLicence: CC BY

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abstract = "Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.",

keywords = "CTC, Ferrofluids, Immunomagnetic separation, Magnetic nanoparticle, Non-specific binding, Positive enrichment, Rare cell detection",

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AB - Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.

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KW - Ferrofluids

KW - Immunomagnetic separation

KW - Magnetic nanoparticle

KW - Non-specific binding

KW - Positive enrichment

KW - Rare cell detection

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JF - Cancers

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Magnetic particles for ctc enrichment

Abstract

Keywords

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