Magnetic particles for ctc enrichment

Peng Liu, Pascal Jonkheijm, Leon W.M.M. Terstappen, Michiel Stevens*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Here, we review the characteristics and synthesis of magnetic nanoparticles (MNPs) and place these in the context of their usage in the immunomagnetic enrichment of Circulating Tumor Cells (CTCs). The importance of the different characteristics is explained, the need for a very specific enrichment is emphasized and different (commercial) magnetic separation techniques are shown. As the specificity of an MNP is in a large part dependent on the antibody coated onto the particle, different strategies in the coupling of specific antibodies as well as an overview of the available antibodies is given.

Original languageEnglish
Article number3525
Pages (from-to)1-26
Number of pages26
JournalCancers
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • CTC
  • Ferrofluids
  • Immunomagnetic separation
  • Magnetic nanoparticle
  • Non-specific binding
  • Positive enrichment
  • Rare cell detection

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