Magnetic polycaprolactone microspheres: drug encapsulation and control

Nesrine Abdelrehim El Gohary*, Abdelrahman Mahmoud, Mohamed Ashraf Nazmy, Rami Zaabalawi, Loaa El Zahar, Islam S.M. Khalil, Mohamed E. Mitwally

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
108 Downloads (Pure)

Abstract

Targeted drug delivery (TDD) systems have several advantages, especially with drugs having toxic side effects such as lornoxicam (LX) which shows high hepatotoxicity and nephrotoxicity, especially with long-term use. This work represents an attempt to control magnetic microspheres encapsulating LX and magnetite nanoparticles (MNPs) for potential targeted drug delivery of LX. Superparamagnetic nanoparticles were fabricated via the co-precipitation method and together with LX were encapsulated into polycaprolactone (PCL) microspheres through an oil-in-water (O/W) emulsion solvent evaporation method. The effects of changing the amount of drug, MNPs, and volume of the aqueous phase were investigated by preparing several microsphere formulations. Increasing the amount of encapsulated MNPs increased the magnetization of the microspheres without affecting the morphology. Doubling the volume of the aqueous phase resulted in a higher encapsulation efficiency and drug loading; 83.9% and 10.7%, respectively, while increasing the amount of drug had a negative effect on both drug loading and encapsulation efficiency. Drug release from the microspheres was successfully achieved and showed a biphasic nature. A system of four planar coils was then used to magnetically control the movement of a cluster of capsules in a glycerin medium, as a simulation for the targeting process. The microspheres were successfully controlled to move in a U-turn path with sharp corners demonstrating their potential for TDD applications.

Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
Volume73
Issue number2
Early online date13 Oct 2022
DOIs
Publication statusPublished - 22 Jan 2024

Keywords

  • 2023 OA procedure
  • lornoxicam
  • magnetic control
  • magnetite
  • polycaprolactone microspheres
  • targeted drug delivery
  • Drug release

Fingerprint

Dive into the research topics of 'Magnetic polycaprolactone microspheres: drug encapsulation and control'. Together they form a unique fingerprint.

Cite this