Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: In vivo demonstration in the rat brain

Wolfgang Dreher; David G. Norris; Dieter Leibfritz

doi:10.1002/mrm.1910310114

Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: In vivo demonstration in the rat brain

Wolfgang Dreher^*
, David G. Norris
, Dieter Leibfritz

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

53 Citations (Scopus)

21 Downloads (Pure)

Abstract

The effect of off‐resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatin/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between ±10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T₂ relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off‐resonance preirradiation. Possible interpretations of these results are discussed.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Magnetic resonance in medicine
Volume	31
Issue number	1
DOIs	https://doi.org/10.1002/mrm.1910310114
Publication status	Published - Jan 1994
Externally published	Yes

Keywords

brain
creatine
magnetization transfer
proton NMR spectroscopy

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10.1002/mrm.1910310114

Magnetic Resonance in Med - January 1994 - DreherFinal published version, 375 KB

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title = "Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: In vivo demonstration in the rat brain",

abstract = "The effect of off‐resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatin/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between ±10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T2 relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off‐resonance preirradiation. Possible interpretations of these results are discussed.",

keywords = "brain, creatine, magnetization transfer, proton NMR spectroscopy",

author = "Wolfgang Dreher and Norris, \{David G.\} and Dieter Leibfritz",

year = "1994",

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T1 - Magnetization transfer affects the proton creatine/phosphocreatine signal intensity

T2 - In vivo demonstration in the rat brain

AU - Dreher, Wolfgang

AU - Norris, David G.

AU - Leibfritz, Dieter

PY - 1994/1

Y1 - 1994/1

N2 - The effect of off‐resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatin/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between ±10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T2 relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off‐resonance preirradiation. Possible interpretations of these results are discussed.

AB - The effect of off‐resonance preirradiation on proton spectra acquired from the healthy rat brain at 4.7 T is examined using a PRESS sequence. The creatin/phosphocreatine (Cr/PCr) signal at 3.0 ppm decreases in signal intensity for offset frequencies between ±10 kHz. This cannot be explained by RF bleedover, but is attributed to magnetization transfer between two pools of Cr/PCr, one with a long T2 relaxation time giving the observed NMR signal, the other corresponding to a broad resonance line being completely or partially saturated by off‐resonance preirradiation. Possible interpretations of these results are discussed.

KW - brain

KW - creatine

KW - magnetization transfer

KW - proton NMR spectroscopy

UR - https://www.scopus.com/pages/publications/0028014341

U2 - 10.1002/mrm.1910310114

DO - 10.1002/mrm.1910310114

M3 - Letter

C2 - 8121275

AN - SCOPUS:0028014341

SN - 0740-3194

VL - 31

SP - 81

EP - 84

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

IS - 1

ER -

Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: In vivo demonstration in the rat brain

Abstract

Keywords

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