Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor

S. Sharifi, W. Mugge, F. Luft, T. Heida, A.C. Schouten, L.J. Bour, A.F. van Rootselaar

Research output: Contribution to conferenceAbstract

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Abstract

Objective: Identifying specifically motor related activation patterns in essential tremor by manipulation of the sensorimotor loop to separate motor activity from sensory feedback during functional magnetic resonance imaging (fMRI) applying a haptic wrist manipulator. Background: Essential tremor is a high prevalent movement disorder with yet unclear pathophysiology and overlapping clinical features with other tremor disorders. In essential tremor efferent motor activity and afferent sensory activity are intermingled, thereby hampering identification of truly tremor related brain areas (efferent drive) in neuroimaging studies1. With help of novel quantitative fMRI approach we manipulate both motor and sensory input to gain insight in the sensorimotor closed loop. Methods: Seven essential tremor patients, diagnosed according to the criteria of the Tremor Investigation Group2(four men; mean age 66±16) with bilateral postural arm tremor, were studied off medication. Subjects performed a motor task with the right hand using a haptic manipulator during fMRI. Tasks included an active isometric motor task (exerting a static torque to the handle) and a passive movement task (going along with a continuous (multi)sinusoidal perturbations). Results were derived from a conventional block-design with random effects analysis of the group comparing active motor tasks and passive motor conditions, with the tasks and the movement parameters used as regressors (FWE corrected, p <0.05). Results: The active motor task versus the passive movement in essential tremor was associated with activation in bilateral cerebellum, bilateral basal ganglia, thalamus, SMA and motor cortex (fig 1). The reversed contrast did not show any activations in motor networks. Conclusions: Our preliminary findings show accurate identification of motor network activity including the cerebellum, thalamus, basal ganglia and motor cortex during isometric contraction versus passive movement. By manipulation of the sensorimotor loop with a wrist manipulator we are able to reveal specific motor network activations. This novel quantitative approach is a promising new technique to study pathophysiological mechanisms in hyperkinetic movement disorders, and potentially lead to new diagnostic approaches.
Original languageEnglish
PagesS424-S424
Publication statusPublished - 8 Jun 2014
Event18th International Congress of Parkinson's Disease and Movement Disorders 2014 - Stockholm, Sweden
Duration: 8 Jun 201412 Jun 2014
Conference number: 18

Conference

Conference18th International Congress of Parkinson's Disease and Movement Disorders 2014
CountrySweden
CityStockholm
Period8/06/1412/06/14

Fingerprint

Essential Tremor
Tremor
Magnetic Resonance Imaging
Motor Activity
Movement Disorders
Motor Cortex
Basal Ganglia
Wrist
Thalamus
Cerebellum
Hyperkinesis
Sensory Feedback
Isometric Contraction
Torque
Neuroimaging
Arm
Hand
Brain

Keywords

  • METIS-308049

Cite this

Sharifi, S., Mugge, W., Luft, F., Heida, T., Schouten, A. C., Bour, L. J., & van Rootselaar, A. F. (2014). Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor. S424-S424. Abstract from 18th International Congress of Parkinson's Disease and Movement Disorders 2014, Stockholm, Sweden.
Sharifi, S. ; Mugge, W. ; Luft, F. ; Heida, T. ; Schouten, A.C. ; Bour, L.J. ; van Rootselaar, A.F. / Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor. Abstract from 18th International Congress of Parkinson's Disease and Movement Disorders 2014, Stockholm, Sweden.
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author = "S. Sharifi and W. Mugge and F. Luft and T. Heida and A.C. Schouten and L.J. Bour and {van Rootselaar}, A.F.",
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Sharifi, S, Mugge, W, Luft, F, Heida, T, Schouten, AC, Bour, LJ & van Rootselaar, AF 2014, 'Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor' 18th International Congress of Parkinson's Disease and Movement Disorders 2014, Stockholm, Sweden, 8/06/14 - 12/06/14, pp. S424-S424.

Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor. / Sharifi, S.; Mugge, W.; Luft, F.; Heida, T.; Schouten, A.C.; Bour, L.J.; van Rootselaar, A.F.

2014. S424-S424 Abstract from 18th International Congress of Parkinson's Disease and Movement Disorders 2014, Stockholm, Sweden.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor

AU - Sharifi, S.

AU - Mugge, W.

AU - Luft, F.

AU - Heida, T.

AU - Schouten, A.C.

AU - Bour, L.J.

AU - van Rootselaar, A.F.

N1 - Meeting abstract 1155

PY - 2014/6/8

Y1 - 2014/6/8

N2 - Objective: Identifying specifically motor related activation patterns in essential tremor by manipulation of the sensorimotor loop to separate motor activity from sensory feedback during functional magnetic resonance imaging (fMRI) applying a haptic wrist manipulator. Background: Essential tremor is a high prevalent movement disorder with yet unclear pathophysiology and overlapping clinical features with other tremor disorders. In essential tremor efferent motor activity and afferent sensory activity are intermingled, thereby hampering identification of truly tremor related brain areas (efferent drive) in neuroimaging studies1. With help of novel quantitative fMRI approach we manipulate both motor and sensory input to gain insight in the sensorimotor closed loop. Methods: Seven essential tremor patients, diagnosed according to the criteria of the Tremor Investigation Group2(four men; mean age 66±16) with bilateral postural arm tremor, were studied off medication. Subjects performed a motor task with the right hand using a haptic manipulator during fMRI. Tasks included an active isometric motor task (exerting a static torque to the handle) and a passive movement task (going along with a continuous (multi)sinusoidal perturbations). Results were derived from a conventional block-design with random effects analysis of the group comparing active motor tasks and passive motor conditions, with the tasks and the movement parameters used as regressors (FWE corrected, p <0.05). Results: The active motor task versus the passive movement in essential tremor was associated with activation in bilateral cerebellum, bilateral basal ganglia, thalamus, SMA and motor cortex (fig 1). The reversed contrast did not show any activations in motor networks. Conclusions: Our preliminary findings show accurate identification of motor network activity including the cerebellum, thalamus, basal ganglia and motor cortex during isometric contraction versus passive movement. By manipulation of the sensorimotor loop with a wrist manipulator we are able to reveal specific motor network activations. This novel quantitative approach is a promising new technique to study pathophysiological mechanisms in hyperkinetic movement disorders, and potentially lead to new diagnostic approaches.

AB - Objective: Identifying specifically motor related activation patterns in essential tremor by manipulation of the sensorimotor loop to separate motor activity from sensory feedback during functional magnetic resonance imaging (fMRI) applying a haptic wrist manipulator. Background: Essential tremor is a high prevalent movement disorder with yet unclear pathophysiology and overlapping clinical features with other tremor disorders. In essential tremor efferent motor activity and afferent sensory activity are intermingled, thereby hampering identification of truly tremor related brain areas (efferent drive) in neuroimaging studies1. With help of novel quantitative fMRI approach we manipulate both motor and sensory input to gain insight in the sensorimotor closed loop. Methods: Seven essential tremor patients, diagnosed according to the criteria of the Tremor Investigation Group2(four men; mean age 66±16) with bilateral postural arm tremor, were studied off medication. Subjects performed a motor task with the right hand using a haptic manipulator during fMRI. Tasks included an active isometric motor task (exerting a static torque to the handle) and a passive movement task (going along with a continuous (multi)sinusoidal perturbations). Results were derived from a conventional block-design with random effects analysis of the group comparing active motor tasks and passive motor conditions, with the tasks and the movement parameters used as regressors (FWE corrected, p <0.05). Results: The active motor task versus the passive movement in essential tremor was associated with activation in bilateral cerebellum, bilateral basal ganglia, thalamus, SMA and motor cortex (fig 1). The reversed contrast did not show any activations in motor networks. Conclusions: Our preliminary findings show accurate identification of motor network activity including the cerebellum, thalamus, basal ganglia and motor cortex during isometric contraction versus passive movement. By manipulation of the sensorimotor loop with a wrist manipulator we are able to reveal specific motor network activations. This novel quantitative approach is a promising new technique to study pathophysiological mechanisms in hyperkinetic movement disorders, and potentially lead to new diagnostic approaches.

KW - METIS-308049

M3 - Abstract

SP - S424-S424

ER -

Sharifi S, Mugge W, Luft F, Heida T, Schouten AC, Bour LJ et al. Manipulation of the sensorimotor loop with a novel quantitative fMRI approach reveals motor networks in essential tremor. 2014. Abstract from 18th International Congress of Parkinson's Disease and Movement Disorders 2014, Stockholm, Sweden.