Mapping optical fluence variations in highly scattering media by measuring ultrasonically modulated backscattered light

Altaf Hussain, Khalid Daoudi, Erwin Hondebrink, Wiendelt Steenbergen

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Abstract

Knowledge of the local optical fluence in biological tissue is of fundamental importance for biomedical optical techniques to achieve quantification. We report a method to noninvasively measure the local optical fluence in optically inhomogeneous scattering media. The concept is based on two aspects: the local tagging of light using ultrasonic modulation and the photon path reversibility principle. Our method has advantages over known computational-based fluence mapping techniques, for its purely experimental nature and without the requirement of prior knowledge of the optical properties of the medium. We provide a theoretical formalism and validation of the method with experiments in tissue-like phantoms. Further, we combine our method with photoacoustic imaging and compensate the photoacoustic signals for fluence variations in optically inhomogeneous media.
Original languageUndefined
Article number066002
Pages (from-to)-
JournalJournal of biomedical optics
Volume19
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • IR-94868
  • METIS-303705

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