TY - JOUR
T1 - Margin assessment during breast conserving surgery using diffuse reflectance spectroscopy
AU - Veluponnar, Dinusha
AU - de Boer, Lisanne L.
AU - Dashtbozorg, Behdad
AU - Jong, Lynn-Jade S.
AU - Geldof, Freija
AU - Da Silva Guimaraes, Marcos
AU - Sterenborg, Henricus J.C.M.
AU - Vrancken-Peeters, Marie-Jeanne T.F.D.
AU - van Duijnhoven, Frederieke
AU - Ruers, Theo
N1 - Publisher Copyright:
© The Authors. Published by SPIE.
PY - 2024/4/25
Y1 - 2024/4/25
N2 - Significance: During breast-conserving surgeries, it is essential to evaluate the resection margins (edges of breast specimen) to determine whether the tumor has been removed completely. In current surgical practice, there are no methods available to aid in accurate real-time margin evaluation.Aim: In this study, we investigated the diagnostic accuracy of diffuse reflectance spectroscopy (DRS) combined with tissue classification models in discriminating tumorous tissue from healthy tissue up to 2 mm in depth on the actual resection margin of in vivo breast tissue.Approach: We collected an extensive dataset of DRS measurements on ex vivo breast tissue and in vivo breast tissue, which we used to develop different classification models for tissue classification. Next, these models were used in vivo to evaluate the performance of DRS for tissue discrimination during breast conserving surgery. We investigated which training strategy yielded optimum results for the classification model with the highest performance.Results: We achieved a Matthews correlation coefficient of 0.76, a sensitivity of 96.7% (95% CI 95.6% to 98.2%), a specificity of 90.6% (95% CI 86.3% to 97.9%) and an area under the curve of 0.98 by training the optimum model on a combination of ex vivo and in vivo DRS data.Conclusions: DRS allows real-time margin assessment with a high sensitivity and specificity during breast-conserving surgeries.
AB - Significance: During breast-conserving surgeries, it is essential to evaluate the resection margins (edges of breast specimen) to determine whether the tumor has been removed completely. In current surgical practice, there are no methods available to aid in accurate real-time margin evaluation.Aim: In this study, we investigated the diagnostic accuracy of diffuse reflectance spectroscopy (DRS) combined with tissue classification models in discriminating tumorous tissue from healthy tissue up to 2 mm in depth on the actual resection margin of in vivo breast tissue.Approach: We collected an extensive dataset of DRS measurements on ex vivo breast tissue and in vivo breast tissue, which we used to develop different classification models for tissue classification. Next, these models were used in vivo to evaluate the performance of DRS for tissue discrimination during breast conserving surgery. We investigated which training strategy yielded optimum results for the classification model with the highest performance.Results: We achieved a Matthews correlation coefficient of 0.76, a sensitivity of 96.7% (95% CI 95.6% to 98.2%), a specificity of 90.6% (95% CI 86.3% to 97.9%) and an area under the curve of 0.98 by training the optimum model on a combination of ex vivo and in vivo DRS data.Conclusions: DRS allows real-time margin assessment with a high sensitivity and specificity during breast-conserving surgeries.
KW - UT-Gold-D
KW - Diffuse reflectance spectroscopy (DRS)
KW - Resection margin assessment
KW - Tissue classification
KW - Breast-conserving surgery
UR - http://www.scopus.com/inward/record.url?scp=85191525992&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.29.4.045006
DO - 10.1117/1.JBO.29.4.045006
M3 - Article
C2 - 38665316
AN - SCOPUS:85191525992
SN - 1083-3668
VL - 29
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 4
M1 - 045006
ER -