Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms

Research output: Contribution to journalArticleAcademicpeer-review

42 Citations (Scopus)

Abstract

During the maintenance period of propofol-induced general anesthesia, specific changes in spontaneous EEG rhythms can be observed. These comprise increased delta and theta power and the emergence of alpha oscillations over frontal regions. In this study we use a meanfield model of the thalamo-cortical system to reproduce these changes and to elucidate the underlying mechanisms. The model is able to reproduce the most dominant changes in the EEG and suggests that they are caused by the amplification of resonances within the thalamo-cortical system. Specifically, while observed increases in delta and alpha power are reflections of amplified resonances in the respective frequency bands, increases in theta power are caused indirectly by spectral power leakage from delta and alpha bands. The model suggests that these changes are brought about through increased inhibition within local cortical interneuron circuits. These results are encouraging and motivate more extensive use of neural meanfield models in elucidating the physiological mechanisms underlying the effects of pharmacological agents on macroscopic brain dynamics
Original languageUndefined
Pages (from-to)2323-2334
JournalNeuroImage
Volume60
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • METIS-292194
  • IR-82943

Cite this

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title = "Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms",
abstract = "During the maintenance period of propofol-induced general anesthesia, specific changes in spontaneous EEG rhythms can be observed. These comprise increased delta and theta power and the emergence of alpha oscillations over frontal regions. In this study we use a meanfield model of the thalamo-cortical system to reproduce these changes and to elucidate the underlying mechanisms. The model is able to reproduce the most dominant changes in the EEG and suggests that they are caused by the amplification of resonances within the thalamo-cortical system. Specifically, while observed increases in delta and alpha power are reflections of amplified resonances in the respective frequency bands, increases in theta power are caused indirectly by spectral power leakage from delta and alpha bands. The model suggests that these changes are brought about through increased inhibition within local cortical interneuron circuits. These results are encouraging and motivate more extensive use of neural meanfield models in elucidating the physiological mechanisms underlying the effects of pharmacological agents on macroscopic brain dynamics",
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author = "Rikkert Hindriks and {van Putten}, {Michel Johannes Antonius Maria}",
year = "2012",
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language = "Undefined",
volume = "60",
pages = "2323--2334",
journal = "NeuroImage",
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publisher = "Academic Press Inc.",
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}

Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms. / Hindriks, Rikkert; van Putten, Michel Johannes Antonius Maria.

In: NeuroImage, Vol. 60, No. 4, 2012, p. 2323-2334.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms

AU - Hindriks, Rikkert

AU - van Putten, Michel Johannes Antonius Maria

PY - 2012

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AB - During the maintenance period of propofol-induced general anesthesia, specific changes in spontaneous EEG rhythms can be observed. These comprise increased delta and theta power and the emergence of alpha oscillations over frontal regions. In this study we use a meanfield model of the thalamo-cortical system to reproduce these changes and to elucidate the underlying mechanisms. The model is able to reproduce the most dominant changes in the EEG and suggests that they are caused by the amplification of resonances within the thalamo-cortical system. Specifically, while observed increases in delta and alpha power are reflections of amplified resonances in the respective frequency bands, increases in theta power are caused indirectly by spectral power leakage from delta and alpha bands. The model suggests that these changes are brought about through increased inhibition within local cortical interneuron circuits. These results are encouraging and motivate more extensive use of neural meanfield models in elucidating the physiological mechanisms underlying the effects of pharmacological agents on macroscopic brain dynamics

KW - METIS-292194

KW - IR-82943

U2 - 10.1016/j.neuroimage.2012.02.042

DO - 10.1016/j.neuroimage.2012.02.042

M3 - Article

VL - 60

SP - 2323

EP - 2334

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

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