Measurement of particle flux in a static matrix with suppressed influence of optical properties, using low coherence interferometry

Babu Varghese, Vinayakrishnan Rajan, Ton G. van Leeuwen, Wiendelt Steenbergen

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Abstract

Perfusion measurements using conventional laser Doppler techniques are affected by the variations in tissue optical properties. Differences in absorption and scattering will induce different path lengths and consequently will alter the probability that a Doppler shift will occur. In this study, the fraction of Doppler shifted photons and the Doppler broadening of a dynamic medium, are measured with a phase modulated low coherence Mach-Zehnder interferometer. Path length-resolved dynamic light scattering measurements are performed in various media having a constant concentration of dynamic particles inside a static matrix with different scattering properties and the results are compared with a conventional laser Doppler technique, with a simple model and with Monte Carlo simulations. We demonstrate that, for larger optical path lengths, the scattering coefficient of the static matrix in which the moving particles are embedded have a small to minimal effect on the measured fraction of Doppler shifted photons and on the measured average Doppler frequency of the Doppler shifted light. This approach has potential applications in measuring perfusion independent of the influence of optical properties in the static tissue matrix.
Original languageEnglish
Pages (from-to)2849-2857
Number of pages9
JournalOptics express
Volume18
Issue number3
DOIs
Publication statusPublished - 2010

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flux (rate)
interferometry
optical properties
matrices
scattering coefficients
photons
Mach-Zehnder interferometers
optical paths
scattering
lasers
light scattering
shift
simulation

Cite this

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title = "Measurement of particle flux in a static matrix with suppressed influence of optical properties, using low coherence interferometry",
abstract = "Perfusion measurements using conventional laser Doppler techniques are affected by the variations in tissue optical properties. Differences in absorption and scattering will induce different path lengths and consequently will alter the probability that a Doppler shift will occur. In this study, the fraction of Doppler shifted photons and the Doppler broadening of a dynamic medium, are measured with a phase modulated low coherence Mach-Zehnder interferometer. Path length-resolved dynamic light scattering measurements are performed in various media having a constant concentration of dynamic particles inside a static matrix with different scattering properties and the results are compared with a conventional laser Doppler technique, with a simple model and with Monte Carlo simulations. We demonstrate that, for larger optical path lengths, the scattering coefficient of the static matrix in which the moving particles are embedded have a small to minimal effect on the measured fraction of Doppler shifted photons and on the measured average Doppler frequency of the Doppler shifted light. This approach has potential applications in measuring perfusion independent of the influence of optical properties in the static tissue matrix.",
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Measurement of particle flux in a static matrix with suppressed influence of optical properties, using low coherence interferometry. / Varghese, Babu; Rajan, Vinayakrishnan; van Leeuwen, Ton G.; Steenbergen, Wiendelt.

In: Optics express, Vol. 18, No. 3, 2010, p. 2849-2857.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Measurement of particle flux in a static matrix with suppressed influence of optical properties, using low coherence interferometry

AU - Varghese, Babu

AU - Rajan, Vinayakrishnan

AU - van Leeuwen, Ton G.

AU - Steenbergen, Wiendelt

PY - 2010

Y1 - 2010

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AB - Perfusion measurements using conventional laser Doppler techniques are affected by the variations in tissue optical properties. Differences in absorption and scattering will induce different path lengths and consequently will alter the probability that a Doppler shift will occur. In this study, the fraction of Doppler shifted photons and the Doppler broadening of a dynamic medium, are measured with a phase modulated low coherence Mach-Zehnder interferometer. Path length-resolved dynamic light scattering measurements are performed in various media having a constant concentration of dynamic particles inside a static matrix with different scattering properties and the results are compared with a conventional laser Doppler technique, with a simple model and with Monte Carlo simulations. We demonstrate that, for larger optical path lengths, the scattering coefficient of the static matrix in which the moving particles are embedded have a small to minimal effect on the measured fraction of Doppler shifted photons and on the measured average Doppler frequency of the Doppler shifted light. This approach has potential applications in measuring perfusion independent of the influence of optical properties in the static tissue matrix.

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