@inproceedings{2353de2146a5450fb2efd0188cdf27ae,
title = "Measurements on Single DNA Molecules",
abstract = "All our understanding of how DNA works is based on evidence obtained with bulk methods. Moreover, information on the detailed conformation of DNA and interactions between DNA and proteins at a high resolution, have been obtained almost entirely under highly nonphysiological conditions (vacuum, low temperature etc.). Recently several methods have become available that make it possible to study individual bio-molecules under physiological conditions. We will describe three of these methods and there application to DNA research: flow analysis of individual molecules, measuring mechanical forces of bio-molecules using optical tweezers and using an AFM to study the dynamics of DNA and DNA protein interactions.",
keywords = "Optical tweezers, DNA overstretching, Denaturation, AFM, Photolyase",
author = "{de Grooth}, B.G. and A. Agronskaia and M.L. Bennink and {van Noort}, S.J.T. and {van der Werf}, K.O. and J. Greve",
year = "1998",
month = mar,
day = "1",
doi = "10.1007/978-94-011-5010-1_7",
language = "English",
isbn = "978-94-010-6103-2",
series = "MESA monographs",
publisher = "Kluwer Academic Publishers",
pages = "43--48",
editor = "{van den Berg}, A. and P. Bergveld",
booktitle = "Sensor technology in the Netherlands - state of the art",
address = "Netherlands",
note = "Dutch Sensor Conference 1998 : Sensor Technology in the Netherlands: State of the Art ; Conference date: 02-03-1998 Through 03-03-1998",
}