Measurements on Single DNA Molecules

B.G. de Grooth, A. Agronskaia, M.L. Bennink, S.J.T. van Noort, K.O. van der Werf, J. Greve

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    All our understanding of how DNA works is based on evidence obtained with bulk methods. Moreover, information on the detailed conformation of DNA and interactions between DNA and proteins at a high resolution, have been obtained almost entirely under highly nonphysiological conditions (vacuum, low temperature etc.). Recently several methods have become available that make it possible to study individual bio-molecules under physiological conditions. We will describe three of these methods and there application to DNA research: flow analysis of individual molecules, measuring mechanical forces of bio-molecules using optical tweezers and using an AFM to study the dynamics of DNA and DNA protein interactions.
    Original languageEnglish
    Title of host publicationSensor technology in the Netherlands - state of the art
    Subtitle of host publicationproceedings of the Dutch Sensor Conference, 2-3 March, 1998, University of Twente, the Netherlands
    EditorsA. van den Berg, P. Bergveld
    Place of PublicationDordrecht
    PublisherKluwer Academic Publishers
    Number of pages6
    ISBN (Electronic)978-94-011-5010-1
    ISBN (Print)978-94-010-6103-2
    Publication statusPublished - 1 Mar 1998
    EventDutch Sensor Conference 1998: Sensor Technology in the Netherlands: State of the Art - University of Twente, Enschede, Netherlands
    Duration: 2 Mar 19983 Mar 1998

    Publication series

    NameMESA monographs
    PublisherKluwer Academic Publishers


    ConferenceDutch Sensor Conference 1998


    • Optical tweezers
    • DNA overstretching
    • Denaturation
    • AFM
    • Photolyase


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