Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays

J. Stegenga, Tjitske Heida

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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Abstract

The symptoms of Parkinson’s disease (a.o.: tremor, rigidity) can be suppressed by electrical stimulation of the basal ganglia. The most common target nucleus of this so called Deep Brain Stimulation (DBS) is the subthalamic nucleus (STN). Good clinical results are obtained by the application of pulses of 200 �?�s, 1-3 V amplitude at a constant rate of about 130 Hz. However, the mechanism(s) responsible for the clinical improvements are not yet elucidated. The use of acute brain slices as a model is widely used, despite the inevitable loss of many connections. Accurate (i.e. subthreshold) measurements of single neuron and multiple neuron (up to ~3, for practical reasons) membrane potentials are obtained by patch-clamp technique. We propose to use arrays of microelectrodes in slice recordings of STN. We present here our first results.
Original languageUndefined
Title of host publicationAnnual symposium of the IEEE-EMBS Benelux Chapter
Place of PublicationEnschede
PublisherTwente University Press (TUP)
Pages26-26
Number of pages1
ISBN (Print)978-90-365-2933-4
Publication statusPublished - 9 Nov 2009
Event4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands
Duration: 9 Nov 200910 Nov 2009
Conference number: 4

Publication series

Name
PublisherTwente University Press

Conference

Conference4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009
CountryNetherlands
CityEnschede
Period9/11/0910/11/09

Keywords

  • METIS-265239
  • EWI-16514
  • BSS-Electrical Neurostimulation
  • IR-68580

Cite this

Stegenga, J., & Heida, T. (2009). Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays. In Annual symposium of the IEEE-EMBS Benelux Chapter (pp. 26-26). Enschede: Twente University Press (TUP).
Stegenga, J. ; Heida, Tjitske. / Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays. Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede : Twente University Press (TUP), 2009. pp. 26-26
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Stegenga, J & Heida, T 2009, Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays. in Annual symposium of the IEEE-EMBS Benelux Chapter. Twente University Press (TUP), Enschede, pp. 26-26, 4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009, Enschede, Netherlands, 9/11/09.

Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays. / Stegenga, J.; Heida, Tjitske.

Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede : Twente University Press (TUP), 2009. p. 26-26.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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Stegenga J, Heida T. Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays. In Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede: Twente University Press (TUP). 2009. p. 26-26