Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays

J. Stegenga, Tjitske Heida

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    Abstract

    The symptoms of Parkinson’s disease (a.o.: tremor, rigidity) can be suppressed by electrical stimulation of the basal ganglia. The most common target nucleus of this so called Deep Brain Stimulation (DBS) is the subthalamic nucleus (STN). Good clinical results are obtained by the application of pulses of 200 �?�s, 1-3 V amplitude at a constant rate of about 130 Hz. However, the mechanism(s) responsible for the clinical improvements are not yet elucidated. The use of acute brain slices as a model is widely used, despite the inevitable loss of many connections. Accurate (i.e. subthreshold) measurements of single neuron and multiple neuron (up to ~3, for practical reasons) membrane potentials are obtained by patch-clamp technique. We propose to use arrays of microelectrodes in slice recordings of STN. We present here our first results.
    Original languageUndefined
    Title of host publicationAnnual symposium of the IEEE-EMBS Benelux Chapter
    Place of PublicationEnschede
    PublisherTwente University Press (TUP)
    Pages26-26
    Number of pages1
    ISBN (Print)978-90-365-2933-4
    Publication statusPublished - 9 Nov 2009
    Event4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands
    Duration: 9 Nov 200910 Nov 2009
    Conference number: 4

    Publication series

    Name
    PublisherTwente University Press

    Conference

    Conference4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009
    CountryNetherlands
    CityEnschede
    Period9/11/0910/11/09

    Keywords

    • METIS-265239
    • EWI-16514
    • BSS-Electrical Neurostimulation
    • IR-68580

    Cite this

    Stegenga, J., & Heida, T. (2009). Measuring activity of the subthalamic nucleus in acute slices using multi electrode arrays. In Annual symposium of the IEEE-EMBS Benelux Chapter (pp. 26-26). Enschede: Twente University Press (TUP).