Measuring reaction kinetics in a lab-on-a-Chip by microcoil NMR

Henk Wensink; Fernando Benito-Lopez; Dorothee C. Hermes; Willem Verboom; Han J.G.E. Gardeniers; David N. Reinhoudt; Albert van den Berg

doi:10.1039/b414832k

Measuring reaction kinetics in a lab-on-a-Chip by microcoil NMR

Henk Wensink, Fernando Benito-Lopez, Dorothee C. Hermes, Willem Verboom, Han J.G.E. Gardeniers, David N. Reinhoudt, Albert van den Berg

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Abstract

A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.

Original language	English
Pages (from-to)	280-284
Number of pages	5
Journal	Lab on a chip
Volume	5
Issue number	3
DOIs	https://doi.org/10.1039/b414832k
Publication status	Published - 2005

Keywords

2023 OA procedure

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10.1039/b414832k

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title = "Measuring reaction kinetics in a lab-on-a-Chip by microcoil NMR",

abstract = "A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.",

keywords = "2023 OA procedure",

author = "Henk Wensink and Fernando Benito-Lopez and Hermes, {Dorothee C.} and Willem Verboom and Gardeniers, {Han J.G.E.} and Reinhoudt, {David N.} and {van den Berg}, Albert",

note = "We acknowledge financial support from the Dutch Technology Foundation (STW) and Avantium Technologies.",

year = "2005",

doi = "10.1039/b414832k",

language = "English",

volume = "5",

pages = "280--284",

journal = "Lab on a chip",

issn = "1473-0197",

publisher = "Royal Society of Chemistry",

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T1 - Measuring reaction kinetics in a lab-on-a-Chip by microcoil NMR

AU - Wensink, Henk

AU - Benito-Lopez, Fernando

AU - Hermes, Dorothee C.

AU - Verboom, Willem

AU - Gardeniers, Han J.G.E.

AU - Reinhoudt, David N.

AU - van den Berg, Albert

N1 - We acknowledge financial support from the Dutch Technology Foundation (STW) and Avantium Technologies.

PY - 2005

Y1 - 2005

N2 - A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.

AB - A microfluidic chip with an integrated planar microcoil was developed for Nuclear Magnetic Resonance (NMR) spectroscopy on samples with volumes of less than a microliter. Real-time monitoring of imine formation from benzaldehyde and aniline in the microreactor chip by NMR was demonstrated. The reaction times in the chip can be set from 30 min down to ca. 2 s, the latter being the mixing time in the microfluidic chip. Design rules will be described to optimize the microreactor and detection coil in order to deal with the inherent sensitivity of NMR and to minimize magnetic field inhomogeneities and obtain sufficient spectral resolution.

KW - 2023 OA procedure

U2 - 10.1039/b414832k

DO - 10.1039/b414832k

M3 - Article

SN - 1473-0197

VL - 5

SP - 280

EP - 284

JO - Lab on a chip

JF - Lab on a chip

IS - 3

ER -

Measuring reaction kinetics in a lab-on-a-Chip by microcoil NMR

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