Mechanical testing of electrospun PCL fibers

F. Croisier, A.-S. Duwez, C. Jerome, A.F. Leanard, Kees van der Werf, Pieter J. Dijkstra, Martin L. Bennink

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Abstract

Poly(ε-caprolactone) (PCL) fibers ranging from 250 to 700 nm in diameter were produced by electrospinning a polymer tetrahydrofuran/N,N-dimethylformamide solution. The mechanical properties of the fibrous scaffolds and individual fibers were measured by different methods. The Young’s moduli of the scaffolds were determined using macro-tensile testing equipment, whereas single fibers were mechanically tested using a nanoscale three-point bending method, based on atomic force microscopy and force spectroscopy analyses. The modulus obtained by tensile-testing eight different fiber scaffolds was 3.8 ± 0.8 MPa. Assuming that PCL fibers can be described by the bending model of isotropic materials, a Young’s modulus of 3.7 ± 0.7 GPa was determined for single fibers. The difference of three orders of magnitude observed in the moduli of fiber scaffolds vs. single fibers can be explained by the lacunar and random structure of the scaffolds.
Original languageUndefined
Pages (from-to)218-224
Number of pages7
JournalActa biomaterialia
Volume8
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • IR-83259
  • METIS-290430

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