Bioaffinity separation principally asks for membranes that show a good compatibility to the targeted biological fluids, provide coupling sites for (bio)ligands and posses a hydrophilic surface to reduce non-specific adsorption caused by hydrophobic atraction. Due to its good blood compatibility and very low water solubility, ethylene vinyl alcohol copolymers(EVAL) has become a promising biomedical membrane material, but has so far not been investigated in detail for (bio)affinity separation. The work reported in this thesis focuses on the preparation of EVAL microporous membrane adsorbers for protein separation based on affinity or ion exchange interaction modes.
|Award date||19 Dec 2002|
|Place of Publication||Enschede|
|Publication status||Published - 19 Dec 2002|