Membrane Engineering: Phase Separation in Polymeric Giant Vesicles

Emeline Rideau, Frederik R. Wurm, Katharina Landfester*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
15 Downloads (Pure)


Cell membranes exhibit elaborate lipidic patterning to carry out a myriad of functions such as signaling and trafficking. Domain formation in giant unilamellar vesicles (GUVs) is thus of interest for understanding fundamental biological processes and to provide new prospects for biocompatible soft materials. Lipid rearrangements in lipidic GUVs and lipid/polymer GUVs are extensively studied whereas polymer/polymer hybrid GUVs remain evasive. Here, the focus is on the thermodynamically driven phase separation of amphiphilic polymers in GUVs. It is demonstrated that polymer phase separation is entropically dictated by hydrophobic block incompatibilities and that films topology can help to determine the outcome of polymeric phase separation in GUVs. Lastly, Janus‐GUVs are obtained and GUVs exhibit a single large domain by using a compatibilizing hydrophobic block copolymer.
Original languageEnglish
Article number1905230
Number of pages7
Issue number27
Publication statusPublished - 28 Jul 2020
Externally publishedYes


  • GUV
  • phase separation
  • polymer blends
  • polymersome
  • synthetic cells


Dive into the research topics of 'Membrane Engineering: Phase Separation in Polymeric Giant Vesicles'. Together they form a unique fingerprint.

Cite this