Memory in cultured cortical networks

Jakob le Feber, T. Witteveen, Irina Stoyanova, Wim Rutten

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic


    Tetanic stimulation was applied to affect network connectivity, as assessed by conditional firing probabilities. We showed that the first period(s) of titanic stimulation at a certain electrode significantly alters functional connectivity, but subsequent, identical stimuli do not. These findings support the hypothesis that isolated networks develop a new balance that supports the activity patterns in response to the stimulus. Accordingly, subsequent stimuli no longer disturb the equilibrium. Similar results were obtained with slow pulses (-0.2 Hz) instead of tetani, suggesting that connectivity changes are driven by network activation, rather than the tetanus itself.
    Original languageUndefined
    Title of host publication8th International Meeting on Substrate-Integrated Microelectrode Arrays
    Place of PublicationReutlingen, Germany
    PublisherNMI University Tuebingen
    Number of pages2
    ISBN (Print)2194-5519
    Publication statusPublished - 10 Jul 2012
    Event8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 - Reutlingen, Germany
    Duration: 10 Jul 201213 Jul 2012
    Conference number: 8

    Publication series

    NameMEA Proceedings
    PublisherNMI University Tuebingen
    ISSN (Print)2194-5519


    Conference8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
    Abbreviated titleMEA


    • EWI-23090
    • BSS-Neurotechnology and cellular engineering
    • METIS-296310
    • cultured cortical networks
    • IR-84227
    • titanic stimulation

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