Memory in cultured cortical networks

Jakob le Feber; T. Witteveen; Irina Stoyanova; Wim Rutten

Memory in cultured cortical networks

Jakob le Feber, T. Witteveen, Irina Stoyanova, Wim Rutten

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

Tetanic stimulation was applied to affect network connectivity, as assessed by conditional firing probabilities. We showed that the first period(s) of titanic stimulation at a certain electrode significantly alters functional connectivity, but subsequent, identical stimuli do not. These findings support the hypothesis that isolated networks develop a new balance that supports the activity patterns in response to the stimulus. Accordingly, subsequent stimuli no longer disturb the equilibrium. Similar results were obtained with slow pulses (-0.2 Hz) instead of tetani, suggesting that connectivity changes are driven by network activation, rather than the tetanus itself.

Original language	Undefined
Title of host publication	8th International Meeting on Substrate-Integrated Microelectrode Arrays
Place of Publication	Reutlingen, Germany
Publisher	NMI University Tuebingen
Pages	70-71
Number of pages	2
ISBN (Print)	2194-5519
Publication status	Published - 10 Jul 2012
Event	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 - Reutlingen, Germany Duration: 10 Jul 2012 → 13 Jul 2012 Conference number: 8

Publication series

Name	MEA Proceedings
Publisher	NMI University Tuebingen
ISSN (Print)	2194-5519

Conference

Conference	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
Abbreviated title	MEA
Country/Territory	Germany
City	Reutlingen
Period	10/07/12 → 13/07/12

Keywords

EWI-23090
BSS-Neurotechnology and cellular engineering
METIS-296310
cultured cortical networks
IR-84227
titanic stimulation

Access to Document

http://eprints.eemcs.utwente.nl/secure2/23090/01/Feber_memory.pdf

Cite this

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title = "Memory in cultured cortical networks",

abstract = "Tetanic stimulation was applied to affect network connectivity, as assessed by conditional firing probabilities. We showed that the first period(s) of titanic stimulation at a certain electrode significantly alters functional connectivity, but subsequent, identical stimuli do not. These findings support the hypothesis that isolated networks develop a new balance that supports the activity patterns in response to the stimulus. Accordingly, subsequent stimuli no longer disturb the equilibrium. Similar results were obtained with slow pulses (-0.2 Hz) instead of tetani, suggesting that connectivity changes are driven by network activation, rather than the tetanus itself.",

keywords = "EWI-23090, BSS-Neurotechnology and cellular engineering, METIS-296310, cultured cortical networks, IR-84227, titanic stimulation",

author = "{le Feber}, Jakob and T. Witteveen and Irina Stoyanova and Wim Rutten",

year = "2012",

month = jul,

day = "10",

language = "Undefined",

isbn = "2194-5519",

series = "MEA Proceedings",

publisher = "NMI University Tuebingen",

pages = "70--71",

booktitle = "8th International Meeting on Substrate-Integrated Microelectrode Arrays",

note = "8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 ; Conference date: 10-07-2012 Through 13-07-2012",

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le Feber, J, Witteveen, T, Stoyanova, I & Rutten, W 2012, Memory in cultured cortical networks. in 8th International Meeting on Substrate-Integrated Microelectrode Arrays. MEA Proceedings, NMI University Tuebingen, Reutlingen, Germany, pp. 70-71, 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012, Reutlingen, Germany, 10/07/12. <http://eprints.eemcs.utwente.nl/secure2/23090/01/Feber_memory.pdf>

TY - GEN

T1 - Memory in cultured cortical networks

AU - le Feber, Jakob

AU - Witteveen, T.

AU - Stoyanova, Irina

AU - Rutten, Wim

N1 - Conference code: 8

PY - 2012/7/10

Y1 - 2012/7/10

N2 - Tetanic stimulation was applied to affect network connectivity, as assessed by conditional firing probabilities. We showed that the first period(s) of titanic stimulation at a certain electrode significantly alters functional connectivity, but subsequent, identical stimuli do not. These findings support the hypothesis that isolated networks develop a new balance that supports the activity patterns in response to the stimulus. Accordingly, subsequent stimuli no longer disturb the equilibrium. Similar results were obtained with slow pulses (-0.2 Hz) instead of tetani, suggesting that connectivity changes are driven by network activation, rather than the tetanus itself.

AB - Tetanic stimulation was applied to affect network connectivity, as assessed by conditional firing probabilities. We showed that the first period(s) of titanic stimulation at a certain electrode significantly alters functional connectivity, but subsequent, identical stimuli do not. These findings support the hypothesis that isolated networks develop a new balance that supports the activity patterns in response to the stimulus. Accordingly, subsequent stimuli no longer disturb the equilibrium. Similar results were obtained with slow pulses (-0.2 Hz) instead of tetani, suggesting that connectivity changes are driven by network activation, rather than the tetanus itself.

KW - EWI-23090

KW - BSS-Neurotechnology and cellular engineering

KW - METIS-296310

KW - cultured cortical networks

KW - IR-84227

KW - titanic stimulation

M3 - Conference contribution

SN - 2194-5519

T3 - MEA Proceedings

SP - 70

EP - 71

BT - 8th International Meeting on Substrate-Integrated Microelectrode Arrays

PB - NMI University Tuebingen

CY - Reutlingen, Germany

T2 - 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012

Y2 - 10 July 2012 through 13 July 2012

ER -