Memory in cultured cortical networks: experiment and modeling

Tim Witteveen, Tamar van Veenendaal, Jakob le Feber

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    The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.
    Original languageUndefined
    Title of host publicationTopical problems of biophotonics
    EditorsA. Sergeev
    Place of PublicationNizhny Novgorod
    PublisherRussian Academy of Sciences
    Number of pages2
    ISBN (Print)9785804800933
    Publication statusPublished - Jul 2013
    EventTopical Problems of Biophotonics International Symposium, TPB 2013 - Nizhny Novgorod, Russia
    Duration: 21 Jul 201327 Jul 2013

    Publication series

    PublisherRussian Academy of Sciences


    ConferenceTopical Problems of Biophotonics International Symposium, TPB 2013
    Other21-27 July 2013


    • EWI-24366
    • METIS-303997
    • IR-89163

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