Memory in cultured cortical networks: experiment and modeling

Tim Witteveen, Tamar van Veenendaal, Jakob le Feber

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.
Original languageUndefined
Title of host publicationTopical problems of biophotonics
EditorsA. Sergeev
Place of PublicationNizhny Novgorod
PublisherRussian Academy of Sciences
Pages225-226
Number of pages2
ISBN (Print)9785804800933
Publication statusPublished - Jul 2013

Publication series

Name
PublisherRussian Academy of Sciences

Keywords

  • EWI-24366
  • METIS-303997
  • IR-89163

Cite this

Witteveen, T., van Veenendaal, T., & le Feber, J. (2013). Memory in cultured cortical networks: experiment and modeling. In A. Sergeev (Ed.), Topical problems of biophotonics (pp. 225-226). Nizhny Novgorod: Russian Academy of Sciences.
Witteveen, Tim ; van Veenendaal, Tamar ; le Feber, Jakob. / Memory in cultured cortical networks: experiment and modeling. Topical problems of biophotonics. editor / A. Sergeev. Nizhny Novgorod : Russian Academy of Sciences, 2013. pp. 225-226
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Witteveen, T, van Veenendaal, T & le Feber, J 2013, Memory in cultured cortical networks: experiment and modeling. in A Sergeev (ed.), Topical problems of biophotonics. Russian Academy of Sciences, Nizhny Novgorod, pp. 225-226.

Memory in cultured cortical networks: experiment and modeling. / Witteveen, Tim; van Veenendaal, Tamar; le Feber, Jakob.

Topical problems of biophotonics. ed. / A. Sergeev. Nizhny Novgorod : Russian Academy of Sciences, 2013. p. 225-226.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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N2 - The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.

AB - The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.

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Witteveen T, van Veenendaal T, le Feber J. Memory in cultured cortical networks: experiment and modeling. In Sergeev A, editor, Topical problems of biophotonics. Nizhny Novgorod: Russian Academy of Sciences. 2013. p. 225-226