Memory in cultured cortical networks: experiment and modeling

Tim Witteveen, Tamar van Veenendaal, Jakob le Feber

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    Abstract

    The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.
    Original languageUndefined
    Title of host publicationTopical problems of biophotonics
    EditorsA. Sergeev
    Place of PublicationNizhny Novgorod
    PublisherRussian Academy of Sciences
    Pages225-226
    Number of pages2
    ISBN (Print)9785804800933
    Publication statusPublished - Jul 2013

    Publication series

    Name
    PublisherRussian Academy of Sciences

    Keywords

    • EWI-24366
    • METIS-303997
    • IR-89163

    Cite this

    Witteveen, T., van Veenendaal, T., & le Feber, J. (2013). Memory in cultured cortical networks: experiment and modeling. In A. Sergeev (Ed.), Topical problems of biophotonics (pp. 225-226). Nizhny Novgorod: Russian Academy of Sciences.
    Witteveen, Tim ; van Veenendaal, Tamar ; le Feber, Jakob. / Memory in cultured cortical networks: experiment and modeling. Topical problems of biophotonics. editor / A. Sergeev. Nizhny Novgorod : Russian Academy of Sciences, 2013. pp. 225-226
    @inproceedings{f2b193c9b0744e7a8584c2c2962ce670,
    title = "Memory in cultured cortical networks: experiment and modeling",
    abstract = "The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.",
    keywords = "EWI-24366, METIS-303997, IR-89163",
    author = "Tim Witteveen and {van Veenendaal}, Tamar and {le Feber}, Jakob",
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    year = "2013",
    month = "7",
    language = "Undefined",
    isbn = "9785804800933",
    publisher = "Russian Academy of Sciences",
    pages = "225--226",
    editor = "A. Sergeev",
    booktitle = "Topical problems of biophotonics",
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    Witteveen, T, van Veenendaal, T & le Feber, J 2013, Memory in cultured cortical networks: experiment and modeling. in A Sergeev (ed.), Topical problems of biophotonics. Russian Academy of Sciences, Nizhny Novgorod, pp. 225-226.

    Memory in cultured cortical networks: experiment and modeling. / Witteveen, Tim; van Veenendaal, Tamar; le Feber, Jakob.

    Topical problems of biophotonics. ed. / A. Sergeev. Nizhny Novgorod : Russian Academy of Sciences, 2013. p. 225-226.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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    T1 - Memory in cultured cortical networks: experiment and modeling

    AU - Witteveen, Tim

    AU - van Veenendaal, Tamar

    AU - le Feber, Jakob

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    N2 - The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.

    AB - The mechanism behind memory is one of the mysteries in neuroscience. Here we unravel part of the mechanism by showing that cultured neuronal networks develop an activity connectivity balance. External inputs disturb this balance and induce connectivity changes. The new connectivity is no longer disrupted by reapplication of the input, indicating that a network memorizes the input. A different input again induces connectivity changes, but returning to the first input no longer affects connectivity, showing that memory traces are stored in parallel. Computer modeling supports these findings, and shows that spike timing dependent plasticity enables neuronal networks to store memory traces of different inputs in parallel.

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    KW - METIS-303997

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    Witteveen T, van Veenendaal T, le Feber J. Memory in cultured cortical networks: experiment and modeling. In Sergeev A, editor, Topical problems of biophotonics. Nizhny Novgorod: Russian Academy of Sciences. 2013. p. 225-226