Mesenchymal stem cells as trophic mediators in cartilage regeneration

Ling Wu

Research output: ThesisPhD Thesis - Research UT, graduation UT

263 Downloads (Pure)


Partial replacement of chondrocytes with stem cells in autologous chondrocyte implantation (ACI) has been proposed as an effective strategy to avoid the in vitro expansion phase of chondrocytes. This expansion phase is necessary to obtain sufficient cells for implantation after harvesting of the cartilage biopsy from the diseased joint. The partial replacement of chondrocytes with stem cells has the potential to bring back the current 2-step surgical procedure to 1-step surgery. Preliminary studies showed that co-culture of primary chondrocytes with various sources of multipotent stem cells increases the relative amount of cartilage matrix formation compared to monocultures of chondrocytes. The molecular mechanism of this chondro-inductive effect is not known. The aim of this thesis is to provide answers to this question.
Original languageEnglish
Awarding Institution
  • University of Twente
  • Karperien, H.B.J., Supervisor
  • van Blitterswijk, Clemens, Supervisor
Award date12 Sep 2012
Place of PublicationEnschede
Print ISBNs9789036533973
Publication statusPublished - 12 Sep 2012


  • IR-81528
  • METIS-288197


Dive into the research topics of 'Mesenchymal stem cells as trophic mediators in cartilage regeneration'. Together they form a unique fingerprint.

Cite this