Mesoscopic concentration fluctuations in a nanofluidic device

Marcel A.G. Zevenbergen; Bernhard L. Wolfrum; Serge G. Lemay

Mesoscopic concentration fluctuations in a nanofluidic device

Marcel A.G. Zevenbergen, Bernhard L. Wolfrum, Serge G. Lemay

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

A direct consequence of downscaling fluidic devices to nanometer dimensions is that the number of molecules being detected or manipulated decreases, ultimately leading to such small numbers of analyte molecules that their discreteness and accompanying statistical fluctuations can no longer be ignored. Here we study these fluctuations both experimentally and theoretically in a nanofluidic cavity capable of detecting ~450 electrochemically active molecules. Due to Brownian motion, the average number of molecules in the device fluctuates, leading to intrinsic fluctuations in the electrochemical signal. We theoretically analyze this diffusive motion and report excellent agreement between the measured and calculated power spectrum densities without fitting parameter.

Original language	English
Title of host publication	Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Editors	Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
Publisher	The Chemical and Biological Microsystems Society
Pages	388-390
Number of pages	3
ISBN (Electronic)	9780979806407
Publication status	Published - 2007
Externally published	Yes
Event	11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007 - Paris, France Duration: 7 Oct 2007 → 11 Oct 2007 Conference number: 11

Conference

Conference	11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007
Abbreviated title	MicroTAS
Country/Territory	France
City	Paris
Period	7/10/07 → 11/10/07

Keywords

Brownian motion
Nanofluidics
Redox cycling

Cite this

Zevenbergen, M. A. G., Wolfrum, B. L., & Lemay, S. G. (2007). Mesoscopic concentration fluctuations in a nanofluidic device. In J.-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 388-390). The Chemical and Biological Microsystems Society.

Zevenbergen, Marcel A.G. ; Wolfrum, Bernhard L. ; Lemay, Serge G. / Mesoscopic concentration fluctuations in a nanofluidic device. Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. editor / Jean-Louis Viovy ; Patrick Tabeling ; Stephanie Descroix ; Laurent Malaquin. The Chemical and Biological Microsystems Society, 2007. pp. 388-390

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abstract = "A direct consequence of downscaling fluidic devices to nanometer dimensions is that the number of molecules being detected or manipulated decreases, ultimately leading to such small numbers of analyte molecules that their discreteness and accompanying statistical fluctuations can no longer be ignored. Here we study these fluctuations both experimentally and theoretically in a nanofluidic cavity capable of detecting ~450 electrochemically active molecules. Due to Brownian motion, the average number of molecules in the device fluctuates, leading to intrinsic fluctuations in the electrochemical signal. We theoretically analyze this diffusive motion and report excellent agreement between the measured and calculated power spectrum densities without fitting parameter.",

keywords = "Brownian motion, Nanofluidics, Redox cycling",

author = "Zevenbergen, {Marcel A.G.} and Wolfrum, {Bernhard L.} and Lemay, {Serge G.}",

year = "2007",

language = "English",

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editor = "Jean-Louis Viovy and Patrick Tabeling and Stephanie Descroix and Laurent Malaquin",

booktitle = "Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007",

publisher = "The Chemical and Biological Microsystems Society",

note = "11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007, MicroTAS ; Conference date: 07-10-2007 Through 11-10-2007",

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Zevenbergen, MAG, Wolfrum, BL & Lemay, SG 2007, Mesoscopic concentration fluctuations in a nanofluidic device. in J-L Viovy, P Tabeling, S Descroix & L Malaquin (eds), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. The Chemical and Biological Microsystems Society, pp. 388-390, 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007, Paris, France, 7/10/07.

Mesoscopic concentration fluctuations in a nanofluidic device. / Zevenbergen, Marcel A.G.; Wolfrum, Bernhard L.; Lemay, Serge G.
Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. ed. / Jean-Louis Viovy; Patrick Tabeling; Stephanie Descroix; Laurent Malaquin. The Chemical and Biological Microsystems Society, 2007. p. 388-390.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - Mesoscopic concentration fluctuations in a nanofluidic device

AU - Zevenbergen, Marcel A.G.

AU - Wolfrum, Bernhard L.

AU - Lemay, Serge G.

N1 - Conference code: 11

PY - 2007

Y1 - 2007

N2 - A direct consequence of downscaling fluidic devices to nanometer dimensions is that the number of molecules being detected or manipulated decreases, ultimately leading to such small numbers of analyte molecules that their discreteness and accompanying statistical fluctuations can no longer be ignored. Here we study these fluctuations both experimentally and theoretically in a nanofluidic cavity capable of detecting ~450 electrochemically active molecules. Due to Brownian motion, the average number of molecules in the device fluctuates, leading to intrinsic fluctuations in the electrochemical signal. We theoretically analyze this diffusive motion and report excellent agreement between the measured and calculated power spectrum densities without fitting parameter.

AB - A direct consequence of downscaling fluidic devices to nanometer dimensions is that the number of molecules being detected or manipulated decreases, ultimately leading to such small numbers of analyte molecules that their discreteness and accompanying statistical fluctuations can no longer be ignored. Here we study these fluctuations both experimentally and theoretically in a nanofluidic cavity capable of detecting ~450 electrochemically active molecules. Due to Brownian motion, the average number of molecules in the device fluctuates, leading to intrinsic fluctuations in the electrochemical signal. We theoretically analyze this diffusive motion and report excellent agreement between the measured and calculated power spectrum densities without fitting parameter.

KW - Brownian motion

KW - Nanofluidics

KW - Redox cycling

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M3 - Conference contribution

AN - SCOPUS:85088679739

SP - 388

EP - 390

BT - Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

A2 - Viovy, Jean-Louis

A2 - Tabeling, Patrick

A2 - Descroix, Stephanie

A2 - Malaquin, Laurent

PB - The Chemical and Biological Microsystems Society

T2 - 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007

Y2 - 7 October 2007 through 11 October 2007

ER -

Mesoscopic concentration fluctuations in a nanofluidic device

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Keywords

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