Abstract
A direct consequence of downscaling fluidic devices to nanometer dimensions is that the number of molecules being detected or manipulated decreases, ultimately leading to such small numbers of analyte molecules that their discreteness and accompanying statistical fluctuations can no longer be ignored. Here we study these fluctuations both experimentally and theoretically in a nanofluidic cavity capable of detecting ~450 electrochemically active molecules. Due to Brownian motion, the average number of molecules in the device fluctuates, leading to intrinsic fluctuations in the electrochemical signal. We theoretically analyze this diffusive motion and report excellent agreement between the measured and calculated power spectrum densities without fitting parameter.
Original language | English |
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Title of host publication | Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 |
Editors | Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin |
Publisher | The Chemical and Biological Microsystems Society |
Pages | 388-390 |
Number of pages | 3 |
ISBN (Electronic) | 9780979806407 |
Publication status | Published - 2007 |
Externally published | Yes |
Event | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007 - Paris, France Duration: 7 Oct 2007 → 11 Oct 2007 Conference number: 11 |
Conference
Conference | 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2007 |
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Abbreviated title | MicroTAS |
Country/Territory | France |
City | Paris |
Period | 7/10/07 → 11/10/07 |
Keywords
- Brownian motion
- Nanofluidics
- Redox cycling