Metal–Organic Frameworks (MOFs) as Multivalent Materials: Size Control and Surface Functionalization by Monovalent Capping Ligands

Timon Rijnaarts, R. Weinhart-Mejia, Richard J.M. Egberink, W.P.E. van Roosmalen, Jurriaan Huskens

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Control over particle size and composition are pivotal to tune the properties of metal organic frameworks (MOFs), for example, for biomedical applications. Particle-size control and functionalization of MIL-88A were achieved by using stoichiometric replacement of a small fraction of the divalent fumarate by monovalent capping ligands. A fluorine-capping ligand was used to quantify the surface coverage of capping ligand at the surface of MIL-88A. Size control at the nanoscale was achieved by using a monovalent carboxylic acid-functionalized poly(ethylene glycol) (PEG-COOH) ligand at different concentrations. Finally, a biotin–carboxylic acid capping ligand was used to functionalize MIL-88A to bind fluorescently labeled streptavidin as an example towards bioapplications.
Original languageUndefined
Pages (from-to)10296-10301
Number of pages6
JournalChemistry : a European journal
Issue number29
Publication statusPublished - 2015


  • METIS-314622
  • IR-99882

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