Control over particle size and composition are pivotal to tune the properties of metal organic frameworks (MOFs), for example, for biomedical applications. Particle-size control and functionalization of MIL-88A were achieved by using stoichiometric replacement of a small fraction of the divalent fumarate by monovalent capping ligands. A fluorine-capping ligand was used to quantify the surface coverage of capping ligand at the surface of MIL-88A. Size control at the nanoscale was achieved by using a monovalent carboxylic acid-functionalized poly(ethylene glycol) (PEG-COOH) ligand at different concentrations. Finally, a biotin–carboxylic acid capping ligand was used to functionalize MIL-88A to bind fluorescently labeled streptavidin as an example towards bioapplications.
Rijnaarts, T., Weinhart-Mejia, R., Egberink, R. J. M., van Roosmalen, W. P. E., & Huskens, J. (2015). Metal–Organic Frameworks (MOFs) as Multivalent Materials: Size Control and Surface Functionalization by Monovalent Capping Ligands. Chemistry: a European journal, 21(29), 10296-10301. https://doi.org/10.1002/chem.201501974