Method of preparing neural tissue of the brain for subsequent electrical stimulation

J. Holsheimer (Inventor)

    Research output: Patent

    46 Downloads (Pure)


    A system and method is described for preferentially stimulating dorsal column fibers while avoiding stimulation of dorsal root fibers. The invention applies hyperpolarizing pre-pulses and depolarizing pre-pulses to neural tissue, such as spinal cord tissue, through a lead placed over the spinal cord having the electrodes arranged on a line approximately transverse to the axis of the spine. To increase the threshold needed to stimulate dorsal root fibers, the anodal pulse given by each lateral contact of the electrodes has to be preceded by a depolarizing pre-pulse and simultaneously, the central electrode contact gives a hyperpolarizing pre-pulse, thereby reducing the stimulation threshold for the dorsal column fibers to subsequent depolarizing pulses.
    Original languageUndefined
    Patent numberUS6892097
    Publication statusAccepted/In press - 10 May 2005


    • BSS-Biomechatronics and rehabilitation technology
    • IR-76036
    • EWI-19670

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