Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film

H.H. Dam; Tanja Tomasberger; David Reinhoudt; Willem Verboom

doi:10.1016/j.aca.2009.01.023

Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film

H.H. Dam, Tanja Tomasberger, David Reinhoudt, Willem Verboom

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Abstract

A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5 Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed.

Original language	Undefined
Pages (from-to)	79-83
Number of pages	5
Journal	Analytica chimica acta
Volume	635
Issue number	1
DOIs	https://doi.org/10.1016/j.aca.2009.01.023
Publication status	Published - 2009

Keywords

Actinides
Am3+ ligand
Combinatorial
Library screening
Photographic film
METIS-263197
IR-79111

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10.1016/j.aca.2009.01.023

Cite this

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title = "Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film",

abstract = "A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5 Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed.",

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T1 - Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film

AU - Dam, H.H.

AU - Tomasberger, Tanja

AU - Reinhoudt, David

AU - Verboom, Willem

PY - 2009

Y1 - 2009

N2 - A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5 Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed.

AB - A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5 Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed.

KW - Actinides

KW - Am3+ ligand

KW - Combinatorial

KW - Library screening

KW - Photographic film

KW - METIS-263197

KW - IR-79111

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DO - 10.1016/j.aca.2009.01.023

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EP - 83

JO - Analytica chimica acta

JF - Analytica chimica acta

IS - 1

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